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Signaling Pathways

9 Items

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  1. LY2784544
    A4147 LY2784544
    Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3K
    Summary: JAK2 inhibitor,highly potent and selective
      ≥23.5 mg/mL
  2. PF-06463922
    B4882 PF-06463922
    Target: ALK|ROS1
    Summary: ALK/ROS1 inhibitor,potent and selective
      insoluble in H2O; ≥20.3 mg/mL
  3. Entrectinib
    B5859 Entrectinib
    Target: Trk Receptors|ALK|ROS1
    Summary: Orally active inhibitor of ALK kinase
      ≥28.05 mg/mL
  4. SB-505124 hydrochloride
    A3799 SB-505124 hydrochloride
    Target: ALK
    Summary: ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selective
  5. LDK378
    A8328 LDK378
    Target: ALK
    Summary: Potent ALK inhibitor
      insoluble in H2O; ≥13.95 mg/mL
  6. GSK1838705A
    A8440 GSK1838705A
    Target: Insulin and Insulin-like Receptors|ALK
    Summary: IGF-IR/IR/ALK inhibitor, ATP-competitive
      ≥26.65 mg/mL
  7. CH5424802
    A8393 CH5424802
    Target: ALK
    Summary: ALK inhibitor,potent and ATP-competitive
  8. AZD-3463
    A8620 AZD-3463
     3 Citation
    Target: ALK|Insulin-like growth factors (IGFs)
    Summary: ALK/IGF1R inhibitor
      insoluble in H2O; insoluble in EtOH; ≥11.22 mg/mL
  9. K02288
    B2286 K02288
    Target: ALK
    Summary: ALK inhibitor
      insoluble in H2O; ≥17.6 mg/mL

9 Items

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