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Signaling Pathways

Items 1-10 of 915

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  1. Inauhzin
    B3272 Inauhzin
    Target: Sir2-like Family Deacetylases (Sirtuins)
    Summary: SIRT1 inhibitor
      ≥23.5 mg/mL
  2. GKT137831
    B4763 GKT137831
     1 Citation
    Target: NADPH Oxidases
    Summary: dual NADPH oxidase Nox1/Nox4 inhibitor
      ≥39.5 mg/mL
  3. Isosafrole
    A8703 Isosafrole
    Target: Lactate Dehydrogenases (LDH)
    Summary: A stiripentol analog, a potent LDH inhibitor.
  4. BLU9931
    A8706 BLU9931
    Target: FGFR
    Summary: FGFR4 inhibitor,potent and irreversible
      ≥50.9 mg/mL
  5. THZ2
    A8717 THZ2
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor
      ≥28.3 mg/mL
  6. CB-5083
    B6032 CB-5083
    Target: p97
    Summary: p97 inhibitor
      insoluble in H2O; ≥20.65 mg/mL
  7. XMU-MP-1
    A8735 XMU-MP-1
     2 Citation
    Target: MST
    Summary: MST1/2 inhibitor, potent and selective
      ≥41.6 mg/mL
  8. Primaquine Diphosphate
    B1820 Primaquine Diphosphate
    Summary: antimalarial agent,blocks protein synthesis
      insoluble in EtOH; ≥18.85 mg/mL
  9. STF-62247
    B2151 STF-62247
    Target: Autophagy
    Summary: Autophagy inducer in renal cell
  10. BMS-345541(free base)
    B4655 BMS-345541(free base)
    Summary: IKK-1/IKK-2 inhibitor,potent and selective
      insoluble in H2O; ≥70 mg/mL

Items 1-10 of 915

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Category
  1. Proteases70item
  2. Apoptosis41item
  3. Chromatin/Epigenetics88item
  4. Metabolism75item
  5. MAPK Signaling41item
  6. Tyrosine Kinase106item
  7. DNA Damage/DNA Repair63item
  8. PI3K/Akt/mTOR Signaling59item
  9. Microbiology & Virology41item
  10. Cell Cycle/Checkpoint60item
  11. Ubiquitination/ Proteasome26item
  12. JAK/STAT Signaling30item
  13. TGF-β / Smad Signaling29item
  14. Angiogenesis7item
  15. GPCR/G protein80item
  16. Stem Cell27item
  17. Membrane Transporter/Ion Channel44item
  18. Cancer Biology2item
  19. Endocrinology and Hormones27item
  20. Neuroscience60item
  21. Obesity, Appetite Control & Diabetes3item
  22. Other Signal Transduction4item
  23. Others93item
  24. Immunology/Inflammation11item
  25. Cardiovascular3item
Reversibility
  1. Reversible47item
  2. Irreversible21item
Target
  1. Caspases7item
  2. Cyclin-Dependent Kinases20item
  3. Adenosine A2A Receptors4item
  4. Proteasome11item
  5. Cathepsins9item
  6. Histone Deacetylases (HDACs)23item
  7. Inhibitor of apoptosis proteins (IAP)3item
  8. Akt6item
  9. Bcl-26item
  10. PI3K26item
  11. CXCR5item
  12. Raf10item
  13. Aurora Kinases11item
  14. Bcl-xl2item
  15. CSF-1R2item
  16. Glycoproteins1 item
  17. p971 item
  18. Gap Junctions2item
  19. MDM22item
  20. EZH24item
  21. mTOR14item
  22. Bromodomains4item
  23. AP-13item
  24. MMP8item
  25. Thymidine Phosphorylases1 item
  26. Androgen Receptors4item
  27. Peptidylprolyl isomerases1 item
  28. Acyl coenzyme A: cholesterol acyltransferases1 item
  29. Myosin II ATPases1 item
  30. DT-diaphorases1 item
  31. Voltage-gated Potassium (KV) Channels2item
  32. MER1 item
  33. FLT312item
  34. GSK-39item
  35. Factor Xa3item
  36. Farnesoid X receptors (FXRs)1 item
  37. LPA Receptors3item
  38. P-glycoprotein (P-gp)6item
  39. PLK6item
  40. Chk7item
  41. Eph Receptors2item
  42. VEGFR26item
  43. PDGFR17item
  44. c-Kit7item
  45. RET3item
  46. Bromodomain-containing proteins(BRDs)1 item
  47. Phosphodiesterases (PDEs)11item
  48. Mcl-14item
  49. Hydrolase1 item
  50. Thymidylate Synthase2item
  51. p389item
  52. PKB1 item
  53. JNK3item
  54. SGK1 item
  55. Bcr-Abl8item
  56. Kynurenine-3-monooxygenase1 item
  57. MEK13item
  58. PORCN1 item
  59. DOT1L3item
  60. FGFR9item
  61. Nrf22item
  62. Insulin-like growth factor receptors(IGFRs)1 item
  63. CGRP receptors2item
  64. Pim3item
  65. GABAB Receptors2item
  66. Liver X receptors (LXRs)2item
  67. Glucagon-like peptide 1 (GLP-1) receptors2item
  68. Sir2-like Family Deacetylases (Sirtuins)4item
  69. Voltage-gated Sodium (NaV) Channels6item
  70. Deubiquitinating enzymes (DUBs)3item
  71. PP11 item
  72. PP2A1 item
  73. Smoothened5item
  74. Eukaryotic elongation factors1 item
  75. Neuraminidases (NA)2item
  76. MET7item
  77. Src5item
  78. RARs8item
  79. Trk Receptors6item
  80. Integrins1 item
  81. Aminopeptidases2item
  82. STAT6item
  83. ATP Citrate Lyases1 item
  84. Microtubules/Tubulins5item
  85. Estrogen and Related Receptors5item
  86. EGFR14item
  87. Hedgehog1 item
  88. ROCK5item
  89. BTK1 item
  90. Purinergic (P2Y) Receptors1 item
  91. RIP kinases1 item
  92. PAK3item
  93. Hypoxia Inducible Factors (HIFs)2item
  94. Tankyrases1 item
  95. Inositol Phosphatases1 item
  96. FAK5item
  97. BMP and Other Activin Receptors3item
  98. JAK12item
  99. p3001 item
  100. Stearoyl-CoA 9-desaturase (SCD-1)1 item
  101. Syk7item
  102. Progesterone Receptors3item
  103. EZH12item
  104. DNA-PK6item
  105. HSP9010item
  106. AMPK5item
  107. Gutathione S-transferase1 item
  108. CCR2item
  109. PDHK1 item
  110. Angiotensin AT2 Receptors2item
  111. Notch1 item
  112. S-nitrosoglutathione reductase1 item
  113. CFTR4item
  114. TNKS1 item
  115. Topoisomerases7item
  116. Cytochrome P450 (CYP450)10item
  117. M3 Receptors2item
  118. thrombin1 item
  119. Ksp1 item
  120. Renin1 item
  121. Influenza viruses1 item
  122. ErbB2item
  123. S6 kinases1 item
  124. Toll-like receptors (TLRs)2item
  125. Adenosine Kinases2item
  126. Actin1 item
  127. DNA Methyltransferases3item
  128. Calcitonin and Related Receptors1 item
  129. Survivin1 item
  130. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs)1 item
  131. ERK5item
  132. HMG-CoA Reductases5item
  133. c-MET8item
  134. BMI-11 item
  135. PKC6item
  136. Calpains5item
  137. CysLT11 item
  138. Ubiquitin-specific proteases1 item
  139. M1 Receptors1 item
  140. HCV Proteases3item
  141. Ca2 /calmodulin-dependent protein kinases (CaMKs)7item
  142. MLK31 item
  143. CREBBP1 item
  144. EP3001 item
  145. Protease-Activated Receptors1 item
  146. Lyn1 item
  147. SGLT2item
  148. RAD511 item
  149. Trypsins1 item
  150. HER22item
  151. Pyk23item
  152. 5-HT2 Receptors12item
  153. LRRK24item
  154. Calcium ionophores1 item
  155. S1P receptors2item
  156. Voltage-gated Calcium Channels (CaV)6item
  157. Calcium chelator1 item
  158. DGAT2item
  159. Insulin and Insulin-like Receptors4item
  160. PARP3item
  161. Prostaglandin EP receptors1 item
  162. CB1 Receptors1 item
  163. Melanocortin (MC) Receptors1 item
  164. Pyruvate dehydrogenases (PDH)1 item
  165. ALK5item
  166. ROS12item
  167. Sphingosine kinases (SphKs)2item
  168. Trypsin1 item
  169. Chymotrypsin1 item
  170. Kallikrein1 item
  171. Trypsinogen1 item
  172. Monocarboxylate transporters (MCTs)1 item
  173. CETP2item
  174. NK1 Receptors1 item
  175. Dehydrogenase1 item
  176. Myosin light chain kinases (MLCKs)1 item
  177. GPR302item
  178. BCPCF efflux1 item
  179. HIV-1 gp1201 item
  180. D1 and D5 Receptors4item
  181. D2 Receptors7item
  182. D3 Receptors4item
  183. 5-HT1 Receptors6item
  184. 5-HT7 Receptors2item
  185. AdipoR11 item
  186. AdipoR21 item
  187. MELK1 item
  188. Serotonin reuptake1 item
  189. Insulin-like growth factors (IGFs)1 item
  190. AMPA1 item
  191. CSF1R1 item
  192. Bromodomain and Extra-Terminal motif (BET)1 item
  193. Lactate Dehydrogenases (LDH)1 item
  194. MK22item
  195. Fatty-acid-binding proteins (FABPs)1 item
  196. 5-HT3 Receptors2item
  197. Angiotensin-Converting Enzymes (ACEs)2item
  198. Tie-24item
  199. RSK2item
  200. p70 S6K1 item
  201. Free Fatty Acid Receptors2item
  202. phosphatases2item
  203. ROS and Other Gaseous Donors1 item
  204. Autophagy3item
  205. ATM/ATR5item
  206. Acetylcholine1 item
  207. COX6item
  208. C5a receptors1 item
  209. Folate Analogue1 item
  210. YAP1 item
  211. Histamine H4 Receptors2item
  212. Farnesyl Diphosphate Synthases1 item
  213. CK22item
  214. HIPK21 item
  215. HIPK31 item
  216. Squalene epoxidases2item
  217. PRAK1 item
  218. MAPKAP-K21 item
  219. Delayed rectifier outward potassium current (IKr)1 item
  220. Melatonin Receptors1 item
  221. 20S proteasomal chymotrypsin1 item
  222. Geranylgeranyltransferase I1 item
  223. Farnesyltransferase1 item
  224. Nampt2item
  225. eIF4F1 item
  226. Cdc421 item
  227. SRPK11 item
  228. P2X Receptors2item
  229. Glutaminases1 item
  230. Carbonic Anhydrases6item
  231. Ron1 item
  232. G9a1 item
  233. BLM1 item
  234. HSV1 item
  235. Adenosine A2B Receptors1 item
  236. NADPH Oxidases2item
  237. Glutamate (Metabotropic) Group I Receptors3item
  238. Calcium-activated chloride channels (CaCC)1 item
  239. GPR351 item
  240. Aldehyde Dehydrogenases2item
  241. Synthases/Synthetases3item
  242. MAGL1 item
  243. NPY Receptors1 item
  244. Leukotriene and Related Receptors1 item
  245. Histamine H1 Receptors9item
  246. RAR/RXR1 item
  247. Sigma Receptors1 item
  248. Na /K ATPases2item
  249. P1101 item
  250. Hck1 item
  251. Inositol-requiring enzyme 1 (IRE1)1 item
  252. Na /K /Cl- Symporters (NKCCs)1 item
  253. GABAA Receptors1 item
  254. Histamine H2 Receptors1 item
  255. Phospholipases1 item
  256. TRP Channel3item
  257. RNA Polymerases3item
  258. Norepinephrine transporter1 item
  259. 5-HT Transporters3item
  260. Ionophores2item
  261. Xanthine oxidoreductases1 item
  262. Dihydroorotate dehydrogenase1 item
  263. Guanylyl Cyclases1 item
  264. FoxM11 item
  265. Histone Demethylases1 item
  266. M2 Receptors1 item
  267. MNK1 item
  268. NO Donors / Precursors1 item
  269. CB2 Receptors1 item
  270. Glucocorticoid Receptors2item
  271. HIV-1 reverse transcriptase1 item
  272. IL Receptors2item
  273. CCL21 item
  274. Norepinephrine transporters1 item
  275. 15-lipoxygenases1 item
  276. Calcium-Activated Potassium (KCa) Channels2item
  277. 5-HT4 Receptors1 item
  278. AChE2item
  279. Insulin Receptors1 item
  280. IRG-1R1 item
  281. cAMP1 item
  282. Sulfonylurea receptors1 item
  283. eEF-21 item
  284. Inward Rectifier Potassium (Kir) Channels4item
  285. Peptidoglycan synthesis1 item
  286. CRTH21 item
  287. Cdc71 item
  288. calcium chelator1 item
  289. Nuclear Receptors1 item
  290. CMV2item
  291. ZAP-701 item
  292. Catechol O-Methyltransferase (COMT)2item
  293. fibrinolysis1 item
  294. Angiotensin AT1 Receptors3item
  295. D4 Receptors2item
  296. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  297. Aldosterone receptor1 item
  298. HBV Proteases1 item
  299. Flk-11 item
  300. Adenine receptors1 item
  301. Papains1 item
  302. RNA synthesis1 item
  303. Protein Arginine Methyltransferases1 item
  304. IMPDH1 item
  305. Na /Ca2 Exchangers (NCXs)1 item
  306. NAE2item
  307. Ubiquitin-activating Enzyme E11 item
  308. SUMOylation1 item
  309. ATGL1 item
  310. BACE1 item
  311. Cytidine deaminases1 item
  312. GPR401 item
  313. Adenylyl Cyclases1 item
  314. angiogenesis1 item
  315. Glucagon Receptors1 item
  316. 15-PGDH1 item
  317. DPP-44item
  318. DREADD Ligands1 item
  319. PP41 item
  320. c-RET1 item
  321. Nonstructural protein 5B (NS5B)1 item
  322. ETA Receptors2item
  323. ETB Receptors1 item
  324. p70 rsk1 item
  325. FPTase1 item
  326. Retinoic acid-related Orphan Receptors (RORs)1 item
  327. ADAMs1 item
  328. TAM kinase1 item
  329. p53-MDM2 interaction1 item
  330. nuclear export1 item
  331. CRM11 item
  332. endothelin receptor1 item
  333. PARs1 item
  334. AXL1 item
  335. Dipeptidyl-peptidase II1 item
  336. adrenoceptor1 item
  337. HDAC1 item
  338. 5-HT6 Receptor1 item
  339. c-Fms tyrosine kinase1 item
  340. PAR1 item
  341. human lyase1 item
  342. Ub-conjugating enzyme (E2) complex1 item
  343. PPAR1 item
  344. IKK1 item
  345. MSK1 item
  346. HCV polymerase1 item
  347. Lyn kinase1 item
  348. Ftase1 item
  349. PC-PLC1 item
  350. Elastases1 item
  351. cannabinoid receptor1 item
  352. Calcium-Sensing Receptors (CaSRs)1 item
  353. Rev-Erb Receptors1 item
  354. Prostanoid Receptors1 item
  355. Retinoid X receptors (RXR)1 item
  356. F1 Fo-ATPase1 item
  357. ITK1 item
  358. NUAK1 item
  359. DCLK21 item
  360. FAAH1 item
  361. TYK21 item
  362. NOP Receptors1 item
  363. Aromatases1 item
  364. PKD1 item
  365. SHIP1 item
  366. MCL11 item
  367. Bcl-w1 item
  368. tropomyosin receptor kinase1 item
  369. LSD1 item
  370. PRMT1 item
  371. GLP1 item
  372. SK1 item
  373. MST1 item
  374. IDO1 item
  375. FXR1 item
  376. Serotonin (5-HT) reuptake1 item
  377. Androgen Receptor1 item
  378. Substance P/NK1 Receptor1 item
  379. gp120/CD41 item
  380. ATM1 item
  381. Sirtuin1 item
  382. NE1 item
  383. CRF1 Receptors1 item
  384. PIKfyve1 item
  385. Glycogen Phosphorylases1 item
  386. MTH11 item
  387. Insulin Receptor1 item
Related Disease
  1. Abscesses And Esophageal Candidiasis1 item
  2. Acne1 item
  3. Acute Disseminated Candidiasis1 item
  4. Acute Kidney Injury1 item
  5. Acute Lung Injury1 item
  6. Acute Myelogenous Leukemia5item
  7. Acute Myeloid Leukemia29item
  8. Acute Renal Failure1 item
  9. Adrenocortical Carcinoma4item
  10. Advanced Renal Cell Carcinoma1 item
  11. Autoimmune Diseases1 item
  12. Bacterial Infectios1 item
  13. Biliary Cancer1 item
  14. Bladder Cancer11item
  15. Bladder Carcinoma4item
  16. Bladder Diseases2item
  17. B-lymphoid Malignancies1 item
  18. Brain Injuries Studies3item
  19. Breast Cancer127item
  20. Cancer453item
  21. Candida Peritonitis1 item
  22. Candidemia1 item
  23. Castration-resistant Prostate Cancer1 item
  24. Cervical Cancer6item
  25. Cholangiocarcinoma2item
  26. Chronic Lymphocytic Leukemia8item
  27. Chronic Myeloproliferative Disorders1 item
  28. Clear Cell Renal Cell Carcinoma2item
  29. Cocaine Abuse1 item
  30. Cocaine-Related Disorders2item
  31. Colon Cancer41item
  32. Colon Carcinoma7item
  33. Colorectal Cancer43item
  34. Depression2item
  35. Diabetes8item
  36. Diffuse Large B-cell Lymphoma1 item
  37. Dyskinesia1 item
  38. Dyslipidemia2item
  39. Epilepsy3item
  40. Erectile Dysfunction3item
  41. Friedreich's Ataxia1 item
  42. Fungal Infection2item
  43. Glioblastoma34item
  44. Glioma19item
  45. HCV2item
  46. Heart Failure1 item
  47. Hepatic Cancer2item
  48. Hepatitis C3item
  49. Hepatocellular Carcinoma8item
  50. HIV4item
  51. HIV Infections12item
  52. Hypercholesterolemia2item
  53. Immunological Diseases1 item
  54. Immunosuppressive Therapy1 item
  55. Inflammation1 item
  56. Inflammatory Bowel Disease1 item
  57. Inflammatory Diseases21item
  58. Influenza2item
  59. Kidney Injury Studies2item
  60. Leukemia28item
  61. Liver Cancer5item
  62. Lung Cancer45item
  63. Lung Carcinoma4item
  64. Lymphoma33item
  65. Mantle Cell Lymphoma2item
  66. Medulloblastoma1 item
  67. Melanoma38item
  68. Mixed Lineage Leukemia3item
  69. Multidrug Resistance Studies1 item
  70. Multiple Myeloma24item
  71. Myelofibrosis2item
  72. Myeloma8item
  73. Narcolepsy1 item
  74. Neuroblastoma15item
  75. Neurocognitive Disorders1 item
  76. Neuronal Protection1 item
  77. Non-small Cell Lung Cancer27item
  78. Non-small Cell Lung Carcinoma3item
  79. Obsessive-Compulsive Disorder1 item
  80. Osteoporosis3item
  81. Ovarian Cancer37item
  82. Pain Relief1 item
  83. Pancreatic Cancer50item
  84. Pancreatic Carcinoma3item
  85. Prostate Cancer57item
  86. Psoriasis6item
  87. Psoriasis Vulgaris1 item
  88. Pulmonary Arterial Hypertension2item
  89. Pulmonary Fibrosis2item
  90. Renal Cancer5item
  91. Renal Cell Carcinoma11item
  92. Rheumatoid Arthritis15item
  93. Sarcoma1 item
  94. Schizophrenia10item
  95. Sleep Disorders2item
  96. Soft Tissue Sarcoma1 item
  97. Squamous Cell Carcinoma3item
  98. Testicular Cancer2item
  99. Thyroid Cancer6item
  100. Tuberculosis2item
  101. Type 2 Diabetes25item