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Signaling Pathways

Items 1-10 of 141

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  1. THZ2
    A8717 THZ2
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor
      ≥28.3 mg/mL
  2. GDC-0068 (RG7440)
    A3006 GDC-0068 (RG7440)
    Target: Akt
    Summary: Pan-AKT inhibitor,highly selective
      ≥22.9 mg/mL
  3. MK-2206 dihydrochloride
    A3010 MK-2206 dihydrochloride
     21 Citation
    Target: Akt
    Summary: Akt1/2/3 inhibitor
      insoluble in EtOH; ≥12.01 mg/mL
  4. Ruxolitinib (INCB018424)
    A3012 Ruxolitinib (INCB018424)
     4 Citation
    Target: JAK
    Summary: JAK inhibitor
      insoluble in H2O; ≥15.32 mg/mL
  5. Trametinib (GSK1120212)
    A3018 Trametinib (GSK1120212)
     7 Citation
    Target: MEK
    Summary: MEK1 and MEK2 inhibitor, potent and selective
      insoluble in H2O; insoluble in EtOH; ≥15.38 mg/mL
  6. MK-0752
    A4006 MK-0752
     1 Citation
    Summary: γ-secretase inhibitor
      ≥22.15 mg/mL
  7. YO-01027 (Dibenzazepine, DBZ)
    A4018 YO-01027 (Dibenzazepine, DBZ)
     1 Citation
    Summary: γ-secretase inhibitor
      ≥23.17 mg/mL
  8. Rocilinostat (ACY-1215)
    A4083 Rocilinostat (ACY-1215)
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: Selective HDAC6 inhibitor
      ≥21.675 mg/mL
  9. JNJ-26481585
    A4090 JNJ-26481585
     3 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: Potent HDAC inhibitor
      insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL
  10. AT13387
    A4056 AT13387
    Target: HSP90
    Summary: Hsp90 inhibitor
      insoluble in H2O; ≥13.25 mg/mL

Items 1-10 of 141

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  1. Proteases11item
  2. Apoptosis9item
  3. Chromatin/Epigenetics19item
  4. Metabolism10item
  5. MAPK Signaling6item
  6. Tyrosine Kinase22item
  7. DNA Damage/DNA Repair19item
  8. PI3K/Akt/mTOR Signaling14item
  9. Microbiology & Virology1 item
  10. Cell Cycle/Checkpoint16item
  11. Ubiquitination/ Proteasome7item
  12. JAK/STAT Signaling10item
  13. TGF-β / Smad Signaling4item
  14. Angiogenesis2item
  15. GPCR/G protein5item
  16. Stem Cell6item
  17. Membrane Transporter/Ion Channel1 item
  18. Endocrinology and Hormones6item
  19. Neuroscience2item
  20. Others6item
  21. Immunology/Inflammation2item
Specificity
  1. Selective135item
Reversibility
  1. Reversible10item
  2. Irreversible4item
Target
  1. Caspases1 item
  2. Cyclin-Dependent Kinases6item
  3. Proteasome2item
  4. Cathepsins1 item
  5. Histone Deacetylases (HDACs)10item
  6. Inhibitor of apoptosis proteins (IAP)2item
  7. Akt3item
  8. Bcl-22item
  9. PI3K8item
  10. CXCR3item
  11. Aurora Kinases4item
  12. Bcl-xl2item
  13. CSF-1R1 item
  14. EZH22item
  15. mTOR5item
  16. Bromodomains1 item
  17. AP-11 item
  18. DT-diaphorases1 item
  19. FLT32item
  20. LPA Receptors1 item
  21. P-glycoprotein (P-gp)1 item
  22. PLK1 item
  23. Chk1 item
  24. VEGFR9item
  25. PDGFR4item
  26. c-Kit3item
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  28. Thymidylate Synthase1 item
  29. p381 item
  30. 3-phosphoglycerate dehydrogenase1 item
  31. Bcr-Abl1 item
  32. MEK5item
  33. PORCN1 item
  34. FGFR2item
  35. Pim1 item
  36. Smoothened2item
  37. MET1 item
  38. Src1 item
  39. RARs1 item
  40. Trk Receptors1 item
  41. STAT2item
  42. Microtubules/Tubulins2item
  43. Estrogen and Related Receptors3item
  44. EGFR8item
  45. FAK1 item
  46. BMP and Other Activin Receptors1 item
  47. JAK2item
  48. Syk1 item
  49. Progesterone Receptors1 item
  50. HSP905item
  51. Topoisomerases1 item
  52. Cytochrome P450 (CYP450)3item
  53. Ksp1 item
  54. ErbB1 item
  55. Survivin1 item
  56. c-MET1 item
  57. PKC3item
  58. Ca2 /calmodulin-dependent protein kinases (CaMKs)1 item
  59. HER22item
  60. PARP1 item
  61. ALK1 item
  62. ROS11 item
  63. GPR301 item
  64. D1 and D5 Receptors1 item
  65. D2 Receptors1 item
  66. D3 Receptors1 item
  67. MELK1 item
  68. CSF1R1 item
  69. Autophagy1 item
  70. ATM/ATR2item
  71. COX1 item
  72. Heparanases1 item
  73. Folate Analogue1 item
  74. CK21 item
  75. HIPK21 item
  76. HIPK31 item
  77. G-quadruplexes1 item
  78. PRAK1 item
  79. MAPKAP-K21 item
  80. 20S proteasomal chymotrypsin1 item
  81. Geranylgeranyltransferase I1 item
  82. Farnesyltransferase1 item
  83. Carbonic Anhydrases1 item
  84. MAGL1 item
  85. Histamine H2 Receptors1 item
  86. FoxM11 item
  87. Glucocorticoid Receptors1 item
  88. Insulin Receptors1 item
  89. IRG-1R1 item
  90. eEF-21 item
  91. D4 Receptors1 item
  92. DPP-41 item
  93. Aromatases2item
Reported Experiments
  1. Animal Experiments133item
  2. Cell Experiments84item