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Signaling Pathways

Items 21-30 of 498

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  1. Lapatinib
    A8218 Lapatinib
     2 Citation
    Target: ErbB
    Summary: EGFR/HER2 inhibitor,potent,selective and reversible
      ≥29.05 mg/mL
  2. Gefitinib (ZD1839)
    A8219 Gefitinib (ZD1839)
     3 Citation
    Target: EGFR
    Summary: Selective EGFR inhibitor
      ≥22.34 mg/mL
  3. GDC-0941
    A8210 GDC-0941
     10 Citation
    Target: PI3K
    Summary: PI3K inhibitor,potent and selective
      ≥25.7 mg/mL
  4. EPZ-6438
    A8221 EPZ-6438
     5 Citation
    Summary: EZH2 inhibitor, potent and selective
      ≥28.64 mg/mL
  5. Ezatiostat
    A8225 Ezatiostat
    Target: Gutathione S-transferase
    Summary: (GST) P1-1 inhibitor
      ≥26.5 mg/mL
  6. Nilotinib(AMN-107)
    A8232 Nilotinib(AMN-107)
     1 Citation
    Target: Bcr-Abl
    Summary: Bcr-Abl kinase inhibitor,selective
      ≥26.5 mg/mL
  7. DMXAA (Vadimezan)
    A8233 DMXAA (Vadimezan)
     2 Citation
    Target: DT-diaphorases
    Summary: Tumnor vascular disrupting agent, apoptosis inducer
      insoluble in H2O; insoluble in EtOH; ≥14.1 mg/mL
  8. Regorafenib
    A8236 Regorafenib
     4 Citation
    Target: Raf|VEGFR|PDGFR|c-Kit|RET
    Summary: Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1
      ≥25.04 mg/mL
  9. PP 1
    A8215 PP 1
    Target: Src|EGFR|JAK|ZAP-70
    Summary: Src family tyrosine kinase inhibitor
  10. Sorafenib Tosylate
    A8245 Sorafenib Tosylate
     1 Citation
    Target: Raf|VEGFR
    Summary: Raf kinases and tyrosine kinases inhibitor
      ≥31.85 mg/mL

Items 21-30 of 498

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Category
  1. Proteases31item
  2. Apoptosis33item
  3. Chromatin/Epigenetics65item
  4. Metabolism30item
  5. MAPK Signaling25item
  6. Tyrosine Kinase84item
  7. DNA Damage/DNA Repair53item
  8. PI3K/Akt/mTOR Signaling36item
  9. Microbiology & Virology5item
  10. Cell Cycle/Checkpoint60item
  11. Ubiquitination/ Proteasome27item
  12. JAK/STAT Signaling26item
  13. TGF-β / Smad Signaling17item
  14. Angiogenesis5item
  15. GPCR/G protein15item
  16. Stem Cell22item
  17. Membrane Transporter/Ion Channel9item
  18. Endocrinology and Hormones12item
  19. Neuroscience10item
  20. Others34item
  21. Immunology/Inflammation6item
Reversibility
  1. Reversible26item
  2. Irreversible17item
Target
  1. Caspases4item
  2. Cyclin-Dependent Kinases20item
  3. Proteasome8item
  4. Cathepsins2item
  5. Histone Deacetylases (HDACs)20item
  6. Inhibitor of apoptosis proteins (IAP)2item
  7. Akt5item
  8. Bcl-25item
  9. PI3K19item
  10. CXCR4item
  11. Raf8item
  12. Aurora Kinases11item
  13. Bcl-xl2item
  14. CSF-1R2item
  15. Glycoproteins1 item
  16. p971 item
  17. MDM22item
  18. EZH25item
  19. mTOR10item
  20. Bromodomains4item
  21. AP-11 item
  22. MMP3item
  23. Thymidine Phosphorylases1 item
  24. Androgen Receptors3item
  25. DT-diaphorases1 item
  26. FLT36item
  27. GSK-34item
  28. LPA Receptors3item
  29. P-glycoprotein (P-gp)6item
  30. PLK6item
  31. Chk5item
  32. ULK11 item
  33. Eph Receptors3item
  34. VEGFR23item
  35. PDGFR15item
  36. c-Kit6item
  37. RET3item
  38. Bromodomain-containing proteins(BRDs)1 item
  39. Phosphodiesterases (PDEs)2item
  40. Mcl-14item
  41. Thymidylate Synthase2item
  42. p383item
  43. 3-phosphoglycerate dehydrogenase1 item
  44. JNK1 item
  45. SGK2item
  46. Bcr-Abl5item
  47. MEK11item
  48. PORCN1 item
  49. DOT1L3item
  50. FGFR8item
  51. Nrf21 item
  52. Insulin-like growth factor receptors(IGFRs)1 item
  53. Pim3item
  54. Sir2-like Family Deacetylases (Sirtuins)2item
  55. Deubiquitinating enzymes (DUBs)3item
  56. PP11 item
  57. PP2A1 item
  58. Smoothened5item
  59. Ribosomal s6 kinases (RSK)1 item
  60. MET7item
  61. Src4item
  62. RARs6item
  63. Trk Receptors4item
  64. Integrins1 item
  65. Aminopeptidases1 item
  66. STAT5item
  67. Microtubules/Tubulins7item
  68. Estrogen and Related Receptors4item
  69. EGFR14item
  70. Hedgehog1 item
  71. PAK3item
  72. Hypoxia Inducible Factors (HIFs)2item
  73. FAK5item
  74. BMP and Other Activin Receptors2item
  75. JAK7item
  76. p3001 item
  77. Stearoyl-CoA 9-desaturase (SCD-1)1 item
  78. Syk4item
  79. Progesterone Receptors2item
  80. EZH11 item
  81. DNA-PK4item
  82. HSP9010item
  83. AMPK2item
  84. Gutathione S-transferase1 item
  85. CCR1 item
  86. eIF4E/eIF3G interaction1 item
  87. Notch1 item
  88. TNKS1 item
  89. Topoisomerases7item
  90. Cytochrome P450 (CYP450)5item
  91. Ksp1 item
  92. ErbB2item
  93. Actin1 item
  94. DNA Methyltransferases3item
  95. Survivin1 item
  96. ERK3item
  97. HMG-CoA Reductases2item
  98. Vacuolar-type ATPase1 item
  99. c-MET7item
  100. BMI-11 item
  101. PKC6item
  102. Calpains2item
  103. Ubiquitin-specific proteases1 item
  104. Ca2 /calmodulin-dependent protein kinases (CaMKs)2item
  105. SMYD21 item
  106. CREBBP1 item
  107. EP3001 item
  108. Lyn1 item
  109. SGLT1 item
  110. RAD511 item
  111. HER21 item
  112. Pyk23item
  113. 5-HT2 Receptors2item
  114. Voltage-gated Calcium Channels (CaV)2item
  115. Calcium chelator1 item
  116. Insulin and Insulin-like Receptors1 item
  117. PARP1 item
  118. ALK4item
  119. ROS12item
  120. Sphingosine kinases (SphKs)1 item
  121. KRAS G12C1 item
  122. Monocarboxylate transporters (MCTs)1 item
  123. Dehydrogenase1 item
  124. PKG1 item
  125. PKA1 item
  126. Myosin light chain kinases (MLCKs)1 item
  127. GPR302item
  128. D1 and D5 Receptors1 item
  129. D2 Receptors2item
  130. D3 Receptors1 item
  131. Valosin-containing protein (VCP)1 item
  132. MELK1 item
  133. Insulin-like growth factors (IGFs)1 item
  134. Integrin-ligand interactions1 item
  135. CSF1R1 item
  136. Bromodomain and Extra-Terminal motif (BET)1 item
  137. MK22item
  138. 5-HT3 Receptors1 item
  139. Angiotensin-Converting Enzymes (ACEs)1 item
  140. Tie-23item
  141. RSK1 item
  142. p70 S6K1 item
  143. Autophagy3item
  144. ATM/ATR6item
  145. COX3item
  146. Heparanases1 item
  147. Folate Analogue1 item
  148. YAP1 item
  149. CK11 item
  150. IDH21 item
  151. Farnesyl Diphosphate Synthases1 item
  152. CK21 item
  153. HIPK21 item
  154. HIPK31 item
  155. G-quadruplexes1 item
  156. PRAK1 item
  157. MAPKAP-K21 item
  158. 20S proteasomal chymotrypsin1 item
  159. Geranylgeranyltransferase I1 item
  160. Farnesyltransferase1 item
  161. Nampt2item
  162. eIF4F1 item
  163. Cdc421 item
  164. P2X Receptors1 item
  165. Glutaminases1 item
  166. Carbonic Anhydrases1 item
  167. Ron1 item
  168. BLM1 item
  169. Aldehyde Dehydrogenases1 item
  170. Synthases/Synthetases3item
  171. MAGL1 item
  172. Histamine H1 Receptors1 item
  173. RAR/RXR1 item
  174. P1101 item
  175. Hck1 item
  176. Inositol-requiring enzyme 1 (IRE1)1 item
  177. iNOS1 item
  178. Histamine H2 Receptors1 item
  179. RNA Polymerases1 item
  180. Norepinephrine transporter1 item
  181. 5-HT Transporters1 item
  182. Guanylyl Cyclases1 item
  183. FoxM11 item
  184. Histone Demethylases1 item
  185. Apoptosis Inducers1 item
  186. Glucocorticoid Receptors1 item
  187. HIV-1 reverse transcriptase1 item
  188. Insulin Receptors1 item
  189. IRG-1R1 item
  190. cAMP1 item
  191. Sulfonylurea receptors1 item
  192. eEF-21 item
  193. Cdc71 item
  194. CMV1 item
  195. ZAP-701 item
  196. Catechol O-Methyltransferase (COMT)1 item
  197. fibrinolysis1 item
  198. D4 Receptors1 item
  199. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  200. Flk-11 item
  201. Papains1 item
  202. RNA synthesis1 item
  203. Protein Arginine Methyltransferases1 item
  204. NAE2item
  205. Ubiquitin-activating Enzyme E11 item
  206. SUMOylation1 item
  207. Cytidine deaminases1 item
  208. angiogenesis1 item
  209. DPP-41 item
  210. PP41 item
  211. TAM kinase1 item
  212. p53-MDM2 interaction1 item
  213. nuclear export1 item
  214. CRM11 item
  215. AXL1 item
  216. human lyase1 item
  217. Ub-conjugating enzyme (E2) complex1 item
  218. MCL11 item
  219. Bcl-w1 item
  220. tropomyosin receptor kinase1 item
  221. LSD1 item
  222. SK1 item
  223. IDO1 item
  224. Substance P/NK1 Receptor1 item
Reported Experiments
  1. Animal Experiments453item
  2. Cell Experiments272item