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Signaling Pathways

Signaling Pathways

B4900 Indoximod (NLG-8189)

Summary: Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor

insoluble in DMSO; insoluble in EtOH; ≥1.12 mg/mL
A8721 CBR-5884
1 Citation

Target: 3-phosphoglycerate dehydrogenase

Summary: selective inhibitor of PHGDH

insoluble in EtOH; insoluble in H2O; ≥16.8 mg/mL
A4056 AT13387

Target: HSP90

Summary: Hsp90 inhibitor

insoluble in H2O; ≥13.25 mg/mL
A4061 IPI-504 (Retaspimycin hydrochloride)
3 Citation

Target: HSP90

Summary: Hsp90 inhibitor,novel, potent,selective

≥26.1 mg/mL
A4064 NVP-BEP800

Target: HSP90

Summary: Oral Hsp90β inhibitor, novel, fully synthetic
A8202 Abiraterone acetate

Target: Cytochrome P450 (CYP450)

Summary: Cytochrome p450 17a1 inhibitor

insoluble in H2O; ≥11.22 mg/mL
A4300 GW9662
1 Citation

Summary: PPARγ antagonist

insoluble in H2O; ≥13.75 mg/mL
A4316 Ketoconazole

Target: Cytochrome P450 (CYP450)

Summary: Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase

≥23.4 mg/mL
A4347 Methotrexate
2 Citation

Target: Folate Analogue

Summary: Folate antagonist,inhibits DFHR

≥21.55 mg/mL
A4358 U-104

Target: Carbonic Anhydrases

Summary: CAIX inhibitor

insoluble in H2O; ≥11.5 mg/mL