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Signaling Pathways

Items 51-60 of 93

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  1. Pemetrexed
    A4390 Pemetrexed
     1 Citation
    Target: Thymidylate Synthase|DHFR|GARFT
    Summary: TS, DHFR,GARFT and AICARFT inhibitor
      insoluble in EtOH; ≥15.68 mg/mL
  2. AN-2728
    A3178 AN-2728
    Summary: PDE4 inhibitor,anti-inflammatory compound
      insoluble in H2O; ≥12.55 mg/mL
  3. Deltarasin
    A3358 Deltarasin
    Target: Phosphodiesterases (PDEs)
    Summary: KRAS-PDEδ interaction inhibitor
      Soluble in DMSO
  4. Dronedarone
    A3374 Dronedarone
    Target: Cytochrome P450 (CYP450)|sodium channel|adrenergic receptor|potassium channel|calcium channel
    Summary: CYP3A4 and 2D6 inhibitor,moderate
      ≥27.84 mg/mL
  5. Fluvastatin
    A3419 Fluvastatin
    Target: HMGCR
    Summary: HMGCR inhibitor
      ≥20.57 mg/mL
  6. GW1929
    A3453 GW1929
    Target: PPAR
    Summary: Potent PPARγ agonist
      ≥ 35 mg/mL
  7. INCB024360 analogue
    A3493 INCB024360 analogue
    Summary: potent and selective inhibitor of IDO1
      ≥13.55 mg/mL
  8. L-165041
    A3536 L-165041
    Target: PPAR
    Summary: PPARβ/δ agonist,cell permeable,potent and selective
      ≥40.2 mg/mL
  9. Levomefolate calcium
    A3552 Levomefolate calcium
    Summary: Artificial form of folate
      insoluble in EtOH; insoluble in DMSO; insoluble in H2O
  10. LX-1031
    A3565 LX-1031
    Target: Tryptophan hydroxylases (TPH)
    Summary: TPH inhibitor
      ≥26.93 mg/mL

Items 51-60 of 93

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Category
  1. PPAR12item
  2. 5-alpha Reductase1 item
  3. 5-Lipoxygenase1 item
  4. C14ɑ demethylase1 item
  5. Carbonic Anhydrase3item
  6. CETP1 item
  7. Cholesterol absorption1 item
  8. CYP3A/CYP4504item
  9. Dehydrogenase6item
  10. DHFR1 item
  11. Dopamine β-hydroxylase4item
  12. FAAH1 item
  13. Factor Xa1 item
  14. Ferroptosis1 item
  15. Folate Analogue1 item
  16. Glucokinase1 item
  17. HMG-CoA Reductase5item
  18. HSP8item
  19. IDO4item
  20. KRAS-PDEδ1 item
  21. Lipid Metabolism1 item
  22. Oxidative Phosphorylation1 item
  23. P4503item
  24. PDE15item
  25. Phospholipase2item
  26. Saccharometabolism1 item
  27. TPH3item
  28. Transferase7item
  29. Hydrolase2item
Specificity
  1. Selective54item
  2. Non-Selective1 item
Reversibility
  1. Irreversible5item
Target
  1. Acyl coenzyme A: cholesterol acyltransferases1 item
  2. Factor Xa1 item
  3. Phosphodiesterases (PDEs)13item
  4. Thymidylate Synthase1 item
  5. RARs1 item
  6. Stearoyl-CoA 9-desaturase (SCD-1)1 item
  7. HSP906item
  8. Cytochrome P450 (CYP450)7item
  9. HMG-CoA Reductases4item
  10. DGAT1 item
  11. Pyruvate dehydrogenases (PDH)1 item
  12. CETP1 item
  13. Lactate Dehydrogenases (LDH)2item
  14. Nampt1 item
  15. Carbonic Anhydrases3item
  16. Aldehyde Dehydrogenases2item
  17. Phospholipases1 item
  18. Inward Rectifier Potassium (Kir) Channels1 item
  19. Catechol O-Methyltransferase (COMT)1 item
  20. Hydroxylases1 item
  21. FPTase1 item
  22. Tryptophan hydroxylases (TPH)2item
  23. sodium channel1 item
  24. PPAR5item
  25. Ftase1 item
  26. PC-PLC1 item
  27. GK1 item
  28. HMGCR1 item
  29. adrenergic receptor1 item
  30. sterol demethylase1 item
  31. GAPDH1 item
  32. complex I of the mitochondrial electron transport chain1 item
  33. potassium channel1 item
  34. calcium channel1 item
  35. FAAH1 item
  36. carnitine reabsorption1 item
  37. 5-alpha Reductases1 item
  38. DHFR1 item
  39. GARFT1 item
  40. glutathione peroxidase 41 item
  41. S-adenosylhomocysteine hydrolase1 item
  42. IDO1 item
  43. Tph1 item
  44. epoxide hydrolase1 item
  45. Cholesterol absorption1 item
  46. Glycogen Phosphorylases1 item
Related Disease
  1. Acne1 item
  2. Acute Kidney Injury1 item
  3. Acute Myeloid Leukemia1 item
  4. Bladder Cancer1 item
  5. Bladder Carcinoma1 item
  6. Brain Injuries Studies1 item
  7. Breast Cancer7item
  8. Cancer27item
  9. Cervical Cancer1 item
  10. Chronic Lymphocytic Leukemia1 item
  11. Cocaine-Related Disorders2item
  12. Colon Cancer1 item
  13. Diabetes4item
  14. Dyslipidemia1 item
  15. Epilepsy1 item
  16. Erectile Dysfunction3item
  17. Fungi1 item
  18. Glioblastoma1 item
  19. Glioma1 item
  20. HIV Infections1 item
  21. Hypercholesterolemia1 item
  22. Inflammation1 item
  23. Inflammatory Diseases1 item
  24. Kidney Injury Studies1 item
  25. Leukemia1 item
  26. Lung Cancer3item
  27. Lymphoma2item
  28. Melanoma4item
  29. Multiple Myeloma3item
  30. Neuroblastoma3item
  31. Neurocognitive Disorders1 item
  32. Non-small Cell Lung Cancer1 item
  33. Obsessive-Compulsive Disorder1 item
  34. Osteoporosis1 item
  35. Pancreatic Cancer2item
  36. Pancreatic Carcinoma1 item
  37. Prostate Cancer7item
  38. Psoriasis2item
  39. Psoriasis Vulgaris1 item
  40. Rheumatoid Arthritis1 item
  41. Schizophrenia1 item
  42. Type 2 Diabetes1 item