JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Home
Signaling Pathways

Signaling Pathways

A4209 NSC 207895 (XI-006)

Target: MDMX

Summary: MDMX inhibitor,anti-cancer agent
A4230 NSC 66811

Summary: MDM2 inhibitor

≥34 mg/mL
A4204 JNJ-26854165 (Serdemetan)
1 Citation

Target: p53|HDM2 ubiquitin ligase

Summary: P53 activator, blocking Mdm2-p53 interaction

insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL
A4202 RITA (NSC 652287)

Summary: Mdm2-p53 interaction and p53 ubiquitination blocking

insoluble in H2O; ≥14.6 mg/mL
B4756 YH239-EE

Summary: p53-MDM2 antagonist, potent

≥50.4 mg/mL
B4813 Pifithrin-β

Summary: potent p53 inhibitor

Soluble in DMSO
B4984 MI-77301 (SAR405838)

Summary: orally available MDM2 antagonist

≥17.2 mg/mL
B6058 (±)-Nutlin-3

Summary: MDM2 antagonist, potent and selective

≥50.1 mg/mL
C4120 SP 141

Summary: Mdm2 inhibitor

≤100 mg/mL
A3762 RG7112
5 Citation

Target: MDM2

Summary: MDM2 inhibitor, first clinical

≥36.4 mg/mL