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Signaling Pathways

Signaling Pathways

A5354 Zonisamide

Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|Carbonic Anhydrases|Calcium-Activated Potassium (KCa) Channels

Summary: Antiepileptic with anticonvulsant and mechanistic effect

insoluble in H2O; ≥8.35 mg/mL
A8513 Riluzole

Target: Voltage-gated Sodium (NaV) Channels|glutamate release

Summary: Sodium channel protein inhibitor

≥23.4 mg/mL
B2274 Proparacaine HCl

Target: Voltage-gated Sodium (NaV) Channels

Summary: voltage-gated sodium channels antagonist

insoluble in EtOH; ≥14.9 mg/mL
B2272 Phenytoin sodium

Target: Voltage-gated Sodium (NaV) Channels

Summary: Sodium channel stabilizer

insoluble in H2O; insoluble in EtOH; ≥11.55 mg/mL
B1420 Bupivacaine HCl

Target: Voltage-gated Sodium (NaV) Channels

Summary: Anaesthetic drug

≥10.25 mg/mL
B2268 Amiloride HCl dihydrate

Target: Voltage-gated Sodium (NaV) Channels|Voltage-gated Calcium Channels (CaV)|Urokinases

Summary: potent epithelial sodium channel (ENaC) blocker

insoluble in EtOH; insoluble in H2O; ≥14.05 mg/mL
B7590 Quinidine

Target: Voltage-gated Sodium (NaV) Channels|Cytochrome P450 (CYP450)

Summary: reduces both Na+ and K+ channel currents
B5515 ProTx II

Target: Voltage-gated Sodium (NaV) Channels

Summary: NaV1.7 channel blocker

Soluble to 1 mg/mL
B2277 A-803467

Target: Voltage-gated Sodium (NaV) Channels

Summary: NaV1.8 channel blocker,potent and selective

insoluble in H2O; ≥13.95 mg/mL
A3418 Flecainide acetate

Target: Voltage-gated Sodium (NaV) Channels

Summary: Antiarrhythmic drug

≥23.7 mg/mL