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Signaling Pathways

Signaling Pathways

A8193 ABT-737
14 Citation

Summary: Bcl-2 inhibitor

≥40.67 mg/mL
A3007 ABT-263 (Navitoclax)
15 Citation

Target: Bcl-2|Bcl-w

Summary: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w

≥48.73 mg/mL
A4234 TW-37
1 Citation

Target: Bcl-2|Bcl-xl|Mcl-1

Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1

insoluble in H2O; ≥19.75 mg/mL
A4194 Obatoclax mesylate (GX15-070)
1 Citation

Target: Bcl-2

Summary: Potent Bcl-2 inhibitor

insoluble in H2O; ≥20.7 mg/mL
A4200 Apogossypolone (ApoG2)
2 Citation

Target: Bcl-2|Bcl-xl|Mcl-1

Summary: Bcl-2 inhibitor,nonpeptidic small molecule

≥24.55 mg/mL
A4199 Sabutoclax
2 Citation

Target: Bcl-2|Mcl-1|Bfl-1

Summary: pan-Bcl-2 inhibitor

insoluble in H2O; ≥205.6 mg/mL
A3196 AT-101

Target: NS3/4a Proteases

Summary: BH3-mimetic,gossypol enantiomer

≥20.7 mg/mL
A3218 BAM7

Summary: BAX activator,direct and selective

soluble in DMSO
A3424 Gambogic Acid

Summary: Caspase activator and apoptosis inducer

≥22.45 mg/mL
A3935 WEHI-539
15 Citation

Target: Bcl-xl

Summary: Bcl-xL inhibitor,potent and selective

insoluble in DMSO; insoluble in H2O; insoluble in EtOH