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Signaling Pathways

Signaling Pathways

A4111 VX-680 (MK-0457,Tozasertib)

Target: Aurora Kinases

Summary: Aurora kinase inhibitor

≥23.25 mg/mL
A4393 Paclitaxel (Taxol)
4 Citation

Target: Microtubules/Tubulins

Summary: Antineoplastic agent

≥85.6 mg/mL
A3214 AZD1152
1 Citation

Target: Aurora Kinases

Summary: Aurora B kinase inhibitor,highly potent and selective

insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL
B1035 Dolastatin 10

Target: Microtubules/Tubulins

Summary: Antitumor agent

≥78.5 mg/mL
A1630 Epothilone B (EPO906, Patupilone)

Target: Microtubules/Tubulins

Summary: Microtubule stabilizing macrolide

≥25.4 mg/mL
A5459 PHA-793887
1 Citation

Target: Cyclin-Dependent Kinases

Summary: Pan-Cdk inhibitor

insoluble in H2O; ≥18.05 mg/mL
A1986 Nu 6027

Target: Cyclin-Dependent Kinases|ATM/ATR

Summary: ATR/CDK inhibitor, potent and selective

insoluble in H2O; ≥12.55 mg/mL
A8477 MK-8776 (SCH-900776)

Target: Chk

Summary: Chk1 inhibitor,potent and selective

insoluble in H2O; insoluble in EtOH; ≥18.8 mg/mL
A8412 Dinaciclib (SCH727965)
2 Citation

Target: Cyclin-Dependent Kinases

Summary: Potent CDK inhibitor
B1288 Rigosertib

Target: PI3K|PLK

Summary: PI3K/PLK1 inhibitor

Soluble in DMSO