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Signaling Pathways

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  1. VX-680 (MK-0457,Tozasertib)
    A4111 VX-680 (MK-0457,Tozasertib)
    Target: Aurora Kinases
    Summary: Aurora kinase inhibitor
      ≥23.25 mg/mL
  2. Aurora A Inhibitor I
    A4126 Aurora A Inhibitor I
    Target: Aurora Kinases
    Summary: Aurora A inhibitor
      ≥29.4 mg/mL
  3. Ro3280
    A8681 Ro3280
    Target: PLK
    Summary: PLK1 inhibitor,potent and highly selective
      ≥27.2 mg/mL
  4. PF-477736
    B1437 PF-477736
    Target: Chk
    Summary: Chk1 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥5.24 mg/mL
  5. Rigosertib
    B1288 Rigosertib
    Target: PI3K|PLK
    Summary: PI3K/PLK1 inhibitor
      Soluble in DMSO

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