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Signaling Pathways

Signaling Pathways

B1642 WYE-125132 (WYE-132)

Target: mTOR

Summary: ATP-competitive mTOR inhibitor, highly potent

insoluble in EtOH; insoluble in H2O; ≥13 mg/mL
B2172 PP121

Target: mTOR|Eph Receptors|VEGFR|PDGFR|Bcr-Abl|Src|DNA-PK|P110|Hck

Summary: Dual inhibitor of tyrosine and phosphoinositide kinases
B1637 OSI-027

Summary: MTORC1/ mTORC2 inhibitor

insoluble in EtOH; insoluble in H2O; ≥32.5 mg/mL
B2227 BI-D1870
1 Citation

Target: p90 S6K

Summary: P90 RSK inhibitor,ATP-competitive and cell-permeable

insoluble in H2O; ≥19.55 mg/mL
B1540 TWS119
1 Citation

Summary: GSK-3β inhibitor

insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL
B1249 TDZD-8
1 Citation

Summary: GSK-3β inhibitor

insoluble in H2O; ≥11.1 mg/mL
B2176 GSK1059615

Target: PI3K|mTOR

Summary: PI3K and mTOR inhibitor,potent and reversible

insoluble in EtOH; insoluble in H2O; ≥8.33 mg/mL
B1640 Torin 2
1 Citation

Target: mTOR|DNA-PK|ATM/ATR

Summary: MTOR inhibitor,highly potent and selective

≥21.6 mg/mL
B2189 YM201636

Target: PIKfyve

Summary: PIKfyve inhibitor,potent and selective

insoluble in H2O; insoluble in EtOH; ≥11.68 mg/mL
B2184 GDC-0980 (RG7422)

Summary: Class I PI3K inhibitor for PI3Kα/β/δ/γ

≥21.35 mg/mL