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Signaling Pathways

Items 21-30 of 351

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  1. Bosutinib (SKI-606)
    A2149 Bosutinib (SKI-606)
     1 Citation
    Target: Bcr-Abl|Src
    Summary: Potent Abl/Src kinases
      ≥26.5 mg/mL
  2. PHA-665752
    A2307 PHA-665752
     1 Citation
    Target: c-MET
    Summary: C-Met inhibitor,potent and ATP-competitive
  3. Ki8751
    A1821 Ki8751
    Target: VEGFR
    Summary: VEGFR-2 inhibitor,potent and selective
      ≥23.45 mg/mL
  4. SU11274
    A2678 SU11274
     2 Citation
    Target: MET
    Summary: C-Met inhibitor,potent and selective
      ≥28.4 mg/mL
  5. Masitinib (AB1010)
    A2942 Masitinib (AB1010)
    Target: PDGFR|c-Kit|Lyn
    Summary: Tyrosine kinase inhibitor, potent and selective
      ≥24.95 mg/mL
  6. AG-1024
    A2673 AG-1024
    Summary: Selective IGF-1R inhibitor
  7. WZ4002
    A1389 WZ4002
    Summary: Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent
      ≥24.7 mg/mL
  8. PF-04217903
    A5096 PF-04217903
    Target: c-MET
    Summary: C-Met inhibitor,selective and ATP-competitive
      insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL
  9. SGX-523
    A1196 SGX-523
     1 Citation
    Target: MET
    Summary: MET inibitor, highly selective, ATP-competitive
      ≥17.95 mg/mL
  10. Linifanib (ABT-869)
    A2949 Linifanib (ABT-869)
    Target: VEGFR|PDGFR
    Summary: VEGFR/PDGFR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥18.75 mg/mL

Items 21-30 of 351

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  1. Bcr-Abl19item
  2. Ack11 item
  3. Axl6item
  4. ALK21item
  5. BMX Kinase1 item
  6. Broad Spectrum Protein Kinase Inhibitor9item
  7. c-FMS2item
  8. c-Kit7item
  9. c-MET24item
  10. c-RET7item
  11. CSF-1R3item
  12. DDR1/DDR2 Receptor1 item
  13. EGFR69item
  14. EphB41 item
  15. FAK10item
  16. FGFR17item
  17. FLT319item
  18. HER214item
  19. IGF1R9item
  20. Insulin Receptor6item
  21. IRAK6item
  22. ITK1 item
  23. Lck1 item
  24. LRRK29item
  25. PDGFR24item
  26. PTKs/RTKs3item
  27. Pyk23item
  28. ROR6item
  29. Spleen Tyrosine Kinase (Syk)12item
  30. Src24item
  31. Tie-2 2item
  32. Trk11item
  33. VEGFR55item
Specificity
  1. Selective118item
Reversibility
  1. Reversible9item
  2. Irreversible8item
Target
  1. Cyclin-Dependent Kinases1 item
  2. Histone Deacetylases (HDACs)1 item
  3. Raf5item
  4. Aurora Kinases3item
  5. CSF-1R4item
  6. MER1 item
  7. FLT312item
  8. Eph Receptors2item
  9. VEGFR37item
  10. PDGFR23item
  11. c-Kit12item
  12. RET3item
  13. IRAK5item
  14. Bcr-Abl12item
  15. FGFR15item
  16. Insulin-like growth factor receptors(IGFRs)1 item
  17. MET7item
  18. Src12item
  19. Trk Receptors5item
  20. STAT1 item
  21. EGFR23item
  22. FAK5item
  23. BMP and Other Activin Receptors3item
  24. JAK2item
  25. Syk6item
  26. ErbB5item
  27. Kinases1 item
  28. c-MET8item
  29. PKC2item
  30. Ca2 /calmodulin-dependent protein kinases (CaMKs)1 item
  31. Lyn2item
  32. HER23item
  33. Pyk23item
  34. LRRK25item
  35. S1P receptors1 item
  36. Insulin and Insulin-like Receptors3item
  37. ALK6item
  38. ROS12item
  39. PKG1 item
  40. PKA1 item
  41. Myosin light chain kinases (MLCKs)1 item
  42. Insulin-like growth factors (IGFs)1 item
  43. CSF1R1 item
  44. Angiotensin-Converting Enzymes (ACEs)1 item
  45. Tie-24item
  46. RSK1 item
  47. p70 S6K1 item
  48. Ron1 item
  49. c-Fyn1 item
  50. 5-Lipoxygenases1 item
  51. Insulin Receptors2item
  52. IRG-1R1 item
  53. ZAP-701 item
  54. Flk-11 item
  55. c-RET2item
  56. TAM kinase1 item
  57. KDR1 item
  58. Fyn kinase1 item
  59. Abl kinases1 item
  60. AXL1 item
  61. c-Fms tyrosine kinase1 item
  62. insulin1 item
  63. Lyn kinase1 item
  64. Mer tyrosine kinase1 item
  65. ErbB-21 item
  66. ITK1 item
  67. DCLK21 item
  68. PTK1 item
  69. Flk11 item
  70. YES1 item
  71. Fyn1 item
  72. enoyl-acyl-carrier protein reductase1 item
  73. tropomyosin receptor kinase1 item
  74. Insulin Receptor1 item
Reported Experiments
  1. Animal Experiments143item
  2. Cell Experiments101item
Related Disease
  1. Acute Myelogenous Leukemia1 item
  2. Acute Myeloid Leukemia5item
  3. Adrenocortical Carcinoma1 item
  4. Advanced Renal Cell Carcinoma1 item
  5. Autoimmune Diseases1 item
  6. Bladder Cancer4item
  7. Bladder Carcinoma1 item
  8. Breast Cancer22item
  9. Cancer110item
  10. Cervical Cancer1 item
  11. Cholangiocarcinoma1 item
  12. Chronic Lymphocytic Leukemia1 item
  13. Clear Cell Renal Cell Carcinoma1 item
  14. Colon Cancer4item
  15. Colon Carcinoma3item
  16. Colorectal Cancer12item
  17. Glioblastoma9item
  18. Glioma4item
  19. Hepatocellular Carcinoma3item
  20. Leukemia3item
  21. Liver Cancer2item
  22. Lung Cancer8item
  23. Lung Carcinoma4item
  24. Lymphoma5item
  25. Melanoma3item
  26. Multiple Myeloma5item
  27. Myeloma1 item
  28. Neuroblastoma2item
  29. Non-small Cell Lung Cancer6item
  30. Ovarian Cancer8item
  31. Pancreatic Cancer12item
  32. Prostate Cancer8item
  33. Pulmonary Arterial Hypertension1 item
  34. Renal Cancer2item
  35. Renal Cell Carcinoma4item
  36. Rheumatoid Arthritis2item
  37. Thyroid Cancer4item