PF-04217903
Catalog No.
A5096
C-Met inhibitor,selective and ATP-competitive
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PF-04217903 (CAS 956905-27-4) is a selective, ATP-competitive inhibitor targeting the receptor tyrosine kinase c-Met, with a reported Ki value of 4.8 nM. Aberrant activation or amplification of c-Met signaling contributes significantly to tumor cell proliferation, angiogenesis, and metastasis. PF-04217903 exhibits high selectivity for c-Met over numerous other kinases and inhibits various c-Met mutants, including R988C, V1092I, H1094R, and T1010I. In cellular studies using lines such as GTL-16 and H1993, PF-04217903 inhibits proliferation and induces apoptosis. In vivo, it effectively reduces c-Met phosphorylation and tumor growth, suggesting potential as a research tool for investigating c-Met-related oncogenic pathways.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 372.38 |
| Cas No. | 956905-27-4 |
| Formula | C19H16N8O |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO |
| Chemical Name | 2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol |
| SDF | Download SDF |
| Canonical SMILES | C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
