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PF-04217903

Catalog No.
A5096
C-Met inhibitor,selective and ATP-competitive
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$83.00
In stock
5mg
$77.00
In stock
25mg
$231.00
In stock
100mg
$517.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

PF-04217903 (CAS 956905-27-4) is a selective, ATP-competitive inhibitor targeting the receptor tyrosine kinase c-Met, with a reported Ki value of 4.8 nM. Aberrant activation or amplification of c-Met signaling contributes significantly to tumor cell proliferation, angiogenesis, and metastasis. PF-04217903 exhibits high selectivity for c-Met over numerous other kinases and inhibits various c-Met mutants, including R988C, V1092I, H1094R, and T1010I. In cellular studies using lines such as GTL-16 and H1993, PF-04217903 inhibits proliferation and induces apoptosis. In vivo, it effectively reduces c-Met phosphorylation and tumor growth, suggesting potential as a research tool for investigating c-Met-related oncogenic pathways.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt372.38
Cas No.956905-27-4
FormulaC19H16N8O
Solubilityinsoluble in EtOH; insoluble in H2O; ≥18.6 mg/mL in DMSO
Chemical Name2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol
SDFDownload SDF
Canonical SMILESC1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

PF-04217903