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Signaling Pathways

Items 141-150 of 241

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  1. LY2811376
    A4020 LY2811376
    Summary: Non-peptidic BACE1 inhibitor
      Soluble in DMSO
  2. BMS-708163 (Avagacestat)
    A4022 BMS-708163 (Avagacestat)
    Summary: γ-secretase inhibitor
      insoluble in H2O; ≥177.6 mg/mL
  3. 17-AAG (KOS953)
    A4054 17-AAG (KOS953)
     3 Citation
    Summary: Hsp90 inhibitor
      ≥24.95 mg/mL
  4. AT13387
    A4056 AT13387
    Target: HSP90
    Summary: Hsp90 inhibitor
      insoluble in H2O; ≥13.25 mg/mL
  5. AUY922 (NVP-AUY922)
    A4057 AUY922 (NVP-AUY922)
     1 Citation
    Target: HSP90
    Summary: Potent Hsp90 inhibitor
      ≥23.27 mg/mL
  6. BIIB021
    A4058 BIIB021
    Target: HSP90
    Summary: Hsp90 inhibitor,selective and competitive
      insoluble in EtOH; insoluble in H2O; ≥14.95 mg/mL
  7. Geldanamycin
    A4060 Geldanamycin
     2 Citation
    Summary: Hsp90 inhibitor,potent and specific
      insoluble in EtOH; insoluble in H2O; ≥16.9 mg/mL
  8. IPI-504 (Retaspimycin hydrochloride)
    A4061 IPI-504 (Retaspimycin hydrochloride)
     3 Citation
    Target: HSP90
    Summary: Hsp90 inhibitor,novel, potent,selective
      ≥26.1 mg/mL
  9. KW-2478
    A4062 KW-2478
    Target: HSP90
    Summary: Potent Hsp90 inhibitor, novel, non-ansamycin,
      ≥100 mg/mL
  10. MPC-3100
    A4063 MPC-3100
    Summary: Hsp90 inhibitor
      Soluble in DMSO

Items 141-150 of 241

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  1. Caspase25item
  2. Aminopeptidase8item
  3. ACE9item
  4. Calpains11item
  5. Carboxypeptidase4item
  6. Cathepsin12item
  7. DPP-418item
  8. Elastase10item
  9. Gamma Secretase18item
  10. HCV Protease15item
  11. HSP25item
  12. HIV Integrase12item
  13. HIV Protease13item
  14. MMP25item
  15. NS3/4a protease4item
  16. Serine Protease9item
  17. Thrombin14item
  18. Urokinase2item
  19. Other Proteases11item
  20. Tyrosinases1 item
Specificity
  1. Selective80item
  2. Non-Selective1 item
Reversibility
  1. Reversible14item
  2. Irreversible13item
Target
  1. Caspases13item
  2. Proteasome1 item
  3. Cathepsins11item
  4. MMP6item
  5. Factor Xa3item
  6. Thymidylate Synthase1 item
  7. Aminopeptidases3item
  8. HSP9012item
  9. Notch1 item
  10. thrombin1 item
  11. Renin1 item
  12. HIV proteases1 item
  13. Pepsins1 item
  14. Serine Proteases2item
  15. Calpains5item
  16. HCV Proteases3item
  17. Trypsins1 item
  18. Trypsin1 item
  19. Chymotrypsin1 item
  20. Kallikrein1 item
  21. Trypsinogen1 item
  22. HIV-1 gp1201 item
  23. HIV Integrases2item
  24. Urokinases1 item
  25. Inward Rectifier Potassium (Kir) Channels1 item
  26. Papains1 item
  27. DPP-45item
  28. Nonstructural protein 5B (NS5B)1 item
  29. ADAMs1 item
  30. Dipeptidyl-peptidase II1 item
  31. metalloprotease1 item
  32. cysteine protease2item
  33. HCV polymerase2item
  34. Subtilisin/Kex2p-like proprotein convertase1 item
  35. Elastases1 item
  36. integrase1 item
  37. HCV NS3-4A protease1 item
  38. NE1 item
Reported Experiments
  1. Animal Experiments90item
  2. Cell Experiments69item
Related Disease
  1. Acute Lung Injury1 item
  2. Acute Myeloid Leukemia1 item
  3. Breast Cancer11item
  4. Cancer35item
  5. Chronic Lymphocytic Leukemia1 item
  6. Clear Cell Renal Cell Carcinoma1 item
  7. Colon Cancer2item
  8. Diabetes3item
  9. Glioma1 item
  10. HCV3item
  11. Hepatitis C4item
  12. HIV4item
  13. HIV Infections2item
  14. Inflammatory Diseases1 item
  15. Lung Cancer3item
  16. Lymphoma1 item
  17. Melanoma7item
  18. Multiple Myeloma2item
  19. Neuroblastoma1 item
  20. Non-small Cell Lung Cancer2item
  21. Osteoporosis1 item
  22. Ovarian Cancer4item
  23. Pancreatic Cancer3item
  24. Prostate Cancer3item
  25. Psoriasis1 item
  26. Renal Cell Carcinoma1 item
  27. Rheumatoid Arthritis3item
  28. Squamous Cell Carcinoma1 item
  29. Type 2 Diabetes1 item