Search results for: 'sirtuin modulator'
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BA5577 HTL14242Summary: HTL14242 (HTL0014242) is an advanced, orally active negatively variable modulator with summed values of 9.3 and 9.2, respectively. - BA5594 ADX71743Summary: ADX71743 is a highly selective, non-competitive and blood-brain barrier-crossing metabotropic glutamate receptor 7 negative mutational modulator.
- BA5654 SamidorphanSummary: Samidorphan (ALKS-33) is an orally active systemic modulator with high affinity for binding to μ-opioid, κ-opioid and δ-opioid receptors.
- BA6902 NS13001Summary: NS13001 is a potent, selective, orally active (small conductance calcium-activated potassium channel) positive allosteric modulator.
- BA5563 BMS-984923Summary: BMS-984923 is a potent silent allosteric modulator with good affinity (K=0.6nM), good oral bioavailability and blood-brain barrier permeability.
- BA6660 AZD7325Summary: AZD7325 is a positive allosteric modulator with oral activity of 0.3and1.3nM, respectively, but is less effective at α1 and α5 receptor subtypes.
- BA5234 RTICBM-189Summary: RTICBM-189 is a potent, cannabinoid type 1 receptor variant modulator that crosses the blood-brain barrier at 7.54 in the Ca mobilization assay.
- BA5498 ML380Summary: ML380 is a potent, subtype-selective and blood-brain-barrier-crossing orthosteric modulator (PAM) with values of 190 and 610 nM for human and rat M5, respectively.
- BA6000 C108297Summary: C108297 is a selective glucocorticoid receptor modulator (GR binding 0.7 nM; GR reporter gene function 0.6 nM).
- BA6198 BNTASummary: BNTA is a potent extracellular matrix modulator that promotes the synthesis of chondrogenic structural molecules on chondrocytes by activating superoxide dismutase 3.