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Home >> Signaling Pathways >> Chromatin/Epigenetics



Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. B3276 MG 149 HAT inhibitor
  3. B3274 CCT007093 PPM1D inhibitor
  4. B3272 Inauhzin SIRT1 inhibitor
  5. A1910 Bromodomain Inhibitor, (+)-JQ1 Top Seller BET bromodomain inhibitor
  6. B6169 I-BRD9 BRD9 inhibitor
  7. B6184 BI-9564 BRD9/7 specific inhibitor
  8. B6196 BI-7273 BRD9 bromodomain inhibitor
  9. B6197 PF-CBP1 CBP/p300 bromodomain inhibitor
  10. B7801 CPI-637 CBP/EP300 bromodomain inhibitor
  11. C3076 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4.
  12. C3668 GSK6853 BRPF1 inhibitor
  13. C4097 NI-57 bromodomains of BRPF proteins inhibitor
  14. C4229 UMB-32 inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factor TAF1 and TAF1L
  15. B5998 GSK2801 inhibitor of BAZ2A and BAZ2B bromodomains
  16. B5973 PFI 4 Potent and selective BRPF1 Bromodomain inhibitor
  17. B5887 BET bromodomain inhibitor Potent and selective inhibitor for BRD4
  18. A8181 (-)-JQ1 Top Seller BET bromodomain inhibitor
  19. A4490 I-CBP 112 CBP/EP300 bromodomain inhibitor
  20. A4491 SGC-CBP30 Inhibitor of CREBBP/EP300 bromodomain,potent
  21. B7744 PFI 3 inhibitor of polybromo 1 and SMARCA4
  22. B5670 I-BET 151 hydrochloride BET bromodomain inhibitor
  23. A9500 GW841819X BET bromodomain inhibitor
  24. B4821 BET-BAY 002 BET inhibitor, potent
  25. B4895 OF-1 BRPF1B and BRPF2 bromodomain inhibitor
  26. B4915 BAZ2-ICR Selective BAZ2 bromodomain inhibitor
  27. B4916 GSK 5959 BRPF1 bromodomain inhibitor
  28. B4917 Ischemin sodium salt CBP bromodomain inhibitor
  29. B4918 OXF BD 02 Selective inhibitor of the first bromodomain of BRD4
  30. B1500 I-BET151 (GSK1210151A) Selective BET inhibitor
  31. B1498 I-BET-762 BET inhibitor,highly potent
  32. B1499 RVX-208 Potent BET bromodomain inhibitor
  33. A8810 UNC669 L3MBTL antagonist,potent and selective
  34. A3901 UNC1215 Chemical probe for the methyllysine (Kme)
  35. A3692 OTX-015 BRD inhibitor
  36. A3445 GSK 525768A inactive stereoisomer of I-BET-762
  37. A4186 Bromosporine Bromodomain inhibitor,non-selective
  38. A4184 PFI-1 (PF-6405761) BET inhibitor
  39. B1081 CPI-203 BET bromodomain inhibitor
  40. B1013 GSK1324726A BET proteins inhibitor
  41. B1012 MS436 BRD4 inhibitor
  42. A4113 ZM 447439 Aurora Kinase inhibitor,potent and selective
  43. A8807 MK-8745 Aurora A inhibitor,potent and selective
  44. A3760 Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
  45. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  46. A4112 Barasertib (AZD1152-HQPA) Top Seller Aurora Kinase B inhibitor, Potent and selective
  47. A4111 VX-680 (MK-0457,Tozasertib) Top Seller Aurora kinase inhibitor
  48. A4110 MLN8237 (Alisertib) Top Seller Aurora A Kinase inhibitor, Potent and selective
  49. A3804 SCH-1473759 Aurora A/B inhibitor
  50. A3939 XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor
  51. A4489 TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective
  52. B6014 BI-847325 dual inhibitor of MEK and Aurora kinases
  53. C3823 Phthalazinone pyrazole Aurora A kinase inhibitor
  54. A4128 PF-03814735 Aurora A/B inhibitor
  55. A4127 GSK1070916 Aurora B/C inhibitor
  56. A4126 Aurora A Inhibitor I Aurora A inhibitor
  57. A4130 ENMD-2076 Selective Aurora A/Flt3 inhibitor
  58. A4129 ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor
  59. A4132 CCT137690 Aurora A/B/C inhibitor
  60. A4118 Hesperadin Top Seller Aurora B kinase inhibitor
  61. A4119 AMG-900 Aurora kinase inhibitor
  62. A4121 SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective
  63. A4124 TAK-901 Novel Aurora A/B inhibitor
  64. A4125 CYC116 Potent Aurora A/B inhibitor
  65. A4131 CCT129202 Aurora kinase inhibitor,ATP-competitive and potent
  66. A4114 MLN8054 Aurora A inhibitor
  67. A4115 JNJ-7706621 Potent CDK/Aurora kinase inhibitor
  68. A4116 Danusertib (PHA-739358) Top Seller Pan-aurora kinase inhibitor
  69. A4117 AT9283 Aurora kinase/JAK inhibitor
  70. A4120 MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective
  71. A4122 PHA-680632 Aurora kinase inhibitor,novel and potent
  72. A4488 Anacardic acid HAT inhibitor
  73. A8191 Nanaomycin A Top Seller DNMT3B inhibitor
  74. A4176 Thioguanine Purine antimetabolite
  75. A1915 Zebularine DNA methylation inhibitor
  76. A1906 Decitabine (NSC127716, 5AZA-CdR) Deoxycytidine analog and cellular diifferentiation inducer
  77. A1907 5-Azacytidine DNA methyltransferase inhibitor.
  78. A1912 Lomeguatrib Top Seller MGMT inhibitor
  79. A1913 RG 108 DNA methyltransferase inhibitor
  80. C4119 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
  81. A8901 Nanaomycin C Amide of nanaomycin A
  82. A4178 SGI-110 DNA methyltransferases inhibitor,potent
  83. A4103 LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel
  84. A4105 M344 Top Seller HDAC inhibitor,potent and cell-permeable
  85. A4501 Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable
  86. A8547 Tubastatin A HCl Top Seller HDAC6 inhibitor,potent and selective
  87. B1141 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
  88. B4890 HPOB HDAC6 inhibitor, potent and selective
  89. A4099 Valproic acid sodium salt (Sodium valproate) HDAC inhibitor
  90. A4098 PCI-24781 (CRA-024781) Pan-HDAC inhibitor
  91. A4096 Belinostat (PXD101) Hydroxamate-type HDAC inhibitor
  92. A8171 Entinostat (MS-275,SNDX-275) Top Seller HDAC1 and HDAC3 inhibitor
  93. A8178 Panobinostat (LBH589) Top Seller HDAC inhibitor
  94. A8183 Trichostatin A (TSA) Top Seller HDAC inhibitor
  95. A8176 Apicidin Potent HDAC inhibitor
  96. A4084 Vorinostat (SAHA, MK0683) Top Seller HDAC inhibitor
  97. A4089 Mocetinostat (MGCD0103, MG0103) Top Seller HDAC inhibitor,isotype-selective and potent
  98. A4090 JNJ-26481585 Top Seller Potent HDAC inhibitor
  99. A4108 Resminostat (RAS2410) Potent HDAC inhibitor
  100. A4095 Pracinostat (SB939) Top Seller Pan-HDAC inhibitor
  101. B5967 UF 010 Novel and selective class I HDAC inhibitor
  102. B5968 BML-210(CAY10433) Novel HDAC inhibitor
  103. B5969 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  104. B5976 Suberohydroxamic Acid HDAC inhibitor
  105. B7816 ITSA-1 (ITSA1) HDAC activator via Trichostatin A (TSA) suppression
  106. C4018 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
  107. C5334 BRD6688 HDAC inhibitor
  108. B5949 BG45 Novel HDAC3-selective inhibitor
  109. B5936 ACY-241 Selective and orally active HDAC6 inhibitor
  110. B5916 Chidamide Novel HDAC inhibitor
  111. N1315 Parthenolide Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)
  112. A4083 Rocilinostat (ACY-1215) Top Seller Selective HDAC6 inhibitor
  113. A4097 CUDC-907 Potent PI3K/HDAC inhibitor
  114. A4100 Droxinostat Selective HDAC inhibitor
  115. A4101 Tubastatin A HDAC6 inhibitor,potent and selective
  116. A3761 RG2833 Brain-penetrant HDAC inhibitor
  117. A8806 TMP269 HDAC 4/5/7/9 inhibitor
  118. A9906 HDAC Set I For inhibiting HDAC
  119. A8803 RGFP966 Specific HDAC3 inhibitor
  120. A4493 KD 5170 HDAC inhibitor
  121. A3305 CHAPS Zwitterionic detergent for membrane proteins,nondenaturing
  122. A4102 CI994 (Tacedinaline) Top Seller HDAC inhibitor
  123. A3755 Resminostat hydrochloride HDAC inhibitor
  124. A3860 Tasquinimod Antiangiogenic and antineoplastic agent
  125. A8173 Romidepsin (FK228, depsipeptide) Top Seller HDAC1/HDAC2 inhibitor,potent and selective
  126. A3348 Daminozide KDM2A inhibitor
  127. A4494 LMK 235 HDAC4/HDAC5 inhibitor
  128. A4498 SBHA HDAC1/HDAC3 inhibitor,cell-permeable
  129. A4500 TCS HDAC6 20b Selective HDAC6 inhibitor
  130. A4091 PCI-34051 HDAC8 inhibitor,potent and selective
  131. A4092 CUDC-101 Multitargeted HDAC inhibitor
  132. A4093 ITF2357 (Givinostat) Top Seller HDAC inhibitor
  133. A4107 Sodium Phenylbutyrate Histone deacetylase inhibitor
  134. A4106 Scriptaid Top Seller HDAC inhibitor,novel and cell-permeable
  135. A4094 MC1568 Top Seller Class II HDAC inhibitor,potent and selective
  136. A4104 AR-42 (OSU-HDAC42) Top Seller HDAC inhibitor,novel and potent
  137. A4495 NCH 51 Histone deacetylase (HDAC) inhibitor
  138. A4496 NSC 3852 HDAC inhibitor
  139. A4497 Pyroxamide HDAC1 inhibitor
  140. A4499 TC-H 106 HDAC inhibitor
  141. B1251 Valproic acid HDAC1 inhibitor
  142. B4655 BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective
  143. B4106 4SC-202 Class I HDAC inhibitor
  144. B3704 Nexturastat A HDAC6 inhibitor,highly potent and selective
  145. B1577 C646 HAT p300-CBP inhibitor,cell-permeable
  146. C5773 CTPB selective activator of the histone acetyltransferase (HAT) p300
  147. C5000 HAT Inhibitor II inhibitor of the histone acetyltransferase p300
  148. C3209 Butyrolactone 3 histone acetyltransferase Gcn5 inhibitor
  149. C3208 CPTH2 (hydrochloride) inhibitor of HAT activity of Gcn5
  150. A8712 MCB-613 stimulator of steroid receptor coactivator (SRC)
  151. B4946 Garcinol Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
  152. B4945 IWP 12 Potent inhibitor of Porcupine (PORCN)
  153. B4887 Remodelin NAT10 inhibitor
  154. B7679 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
  155. B7250 YM 750 Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
  156. B7241 VULM 1457 Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor
  157. B6987 CI 976 acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor
  158. A4492 NU 9056 KAT5 (Tip60) HAT inhibitor
  159. B7739 L002 p300 inhibitor
  160. B1602 Donepezil HCl AChE inhibitor
  161. A4190 GSK J4 HCl Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable
  162. B5685 GSK J2 inactive control of GSK J1, JMJD3 (KDM6B) and UTX (KDM6A) inhibitor
  163. C3584 PBIT JARID1 family demethylases inhibitor
  164. C3630 Lysine-specific Demethylase Inhibitor (1C) lysine-specific demethylase Inhibitor
  165. C3095 N-Oxalylglycine cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E.
  166. C4247 RN-1 (hydrochloride) LSD1 inhibitor
  167. C4202 GSK-LSD1 (hydrochloride) LSD1 inhibitor
  168. C5162 Bizine LSD1 inhibitor
  169. A8766 OG-L002 HCl LSD1 inhibitor,potent and specific
  170. B7514 Tranylcypromine hydrochloride LSD1/BHC110 and monoamine oxidase (MAO) inhibitor
  171. B7811 CPI-455 KDM5 inhibitor
  172. B6084 AS8351 histone demethylase inhibitor
  173. B5972 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  174. B5686 GSK J5 inactive isomer of GSK J4, KDM inhibitor
  175. B5784 RN 1 dihydrochloride LSD1 inhibitor, potent and selective
  176. B4835 CBB1003 novel histone demethylase LSD1 inhibitor
  177. B4891 ML324 JMJD2 demethylase inhibitor, potent and cell-permeable
  178. B4894 SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific
  179. B4930 TC-E 5002 Selective histone demethylase KDM2/7 subfamily inhibitor
  180. B4983 GSK-LSD1 2HCl irreversible, and selective LSD1 inhibitor
  181. B5959 GSK J4 free base histone demethylase JMJD3/UTX inhibitor
  182. B5879 GSK2879552 Novel and irreversible LSD1 inhibitor
  183. B5607 IOX 1 histone demethylase JMJD inhibitor
  184. B1580 OG-L002 LSD1 inhibitor,potent and specific
  185. B1578 Tranylcypromine (2-PCPA) HCl Monoamine oxidase inhibitor
  186. B1263 CBB1007 LSD1 inhibitor,potent and selective
  187. A4191 GSK J1 H3K27 demethylase JMJD3 inhibitor
  188. A1905 3-Deazaneplanocin,DZNep Top Seller S-adenosylhomocysteine and EZH2 inhibitor
  189. A1146 Histone-H2A-(107-122)-Ac-OH Histone-H2A peptide
  190. A4171 EPZ005687 Top Seller EZH2 inhibitor,potent and selective
  191. A4168 Entacapone COMT inhibitor
  192. A4166 EPZ5676 DOT1L inhibitor,potent and SAM competitive
  193. B6085 AMI5 protein methyltransferase inhibitor
  194. B6088 EPZ020411 PRMT6 inhibitor
  195. B6119 LLY507 SMYD2 inhibitor
  196. B6120 Adox indirect methyltransferase inhibitor
  197. B6168 OICR-9429 Wdr5-MLL interaction antagonist
  198. B6182 GSK591 PRMT5 inhibitor
  199. B6183 MS023 type I PRMTs inhibitor
  200. B7806 HLCL-61 PRMT5 inhibitor
  201. B7819 CPI-1205 EZH2 inhibitor

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