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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

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  1. Cat.No. Product Name Information
  2. A3002 ABT-888 (Veliparib) Top Seller Potent PARP inhibitor
  3. A4526 BYK 49187 Potent PARP-1/PARP-2 inhibitor
  4. A4527 DR 2313 PARP inhibitor
  5. A4528 EB 47 Potent PARP-1 inhibitor
  6. A4529 JW 55 Top Seller PARP domain inhibitor
  7. A4530 NU 1025 PARP inhibitor,potent and novel
  8. A4531 WIKI4 Inhibitor of Wnt/ß-Catenin signaling and tankyrase
  9. A8600 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
  10. A8601 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
  11. A8808 ME0328 PARP inhibitor,potent and selective
  12. B1163 MK-4827 hydrochloride PARP1/PARP2 inhibitor
  13. B1164 MK-4827 tosylate PARP1/PARP2 inhibitor
  14. A4525 BYK 204165 PARP-1 inhibitor,potent and selective
  15. A4524 4-HQN PARP inhibitor
  16. A4154 Olaparib (AZD2281, Ku-0059436) Top Seller Potent PARP1/PARP2 inhibitor
  17. A4157 Iniparib (BSI-201) PARP1 inhibitor,intravenously adminsitered
  18. A4159 PJ34 hydrochloride Top Seller PARP inhibitor,potent and cell-permeable
  19. A4160 A-966492 PARP-1/-2 inhibitor, highly potent
  20. A4161 INO-1001 Potent PARP inhibitor
  21. A4163 UPF 1069 Selective PARP2 inhibitor
  22. A4164 AZD2461 Novel PARP inhibitor
  23. A3246 BMN-673 8R,9S PARP inhibitor
  24. A3617 MK-4827 PARP-1/-2 inhibitor,potent and selective
  25. A3729 PJ34 PARP-l inhibitor
  26. A3958 Veliparib dihydrochloride PARP-1/PARP-2 inhibitor
  27. B6152 Benzamide poly (ADP-ribose) synthetase inhibitor
  28. B6150 Picolinamide poly (ADP-ribose) synthetase inhibitor
  29. B6086 BGP-15 PARP inhibitor
  30. A1877 XAV-939 Top Seller Tankyrase 1/2 inhibitor
  31. A4158 AG-14361 Potent PARP1 inhibitor
  32. A4156 Rucaparib (AG-014699,PF-01367338) Top Seller Potent PARP inhibitor
  33. A4153 BMN 673 Top Seller Potent PARP inhibitor
  34. C4310 4-amino-1,8-Naphthalimide PARP inhibitor