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Recombinant Human IL-21, Tag Free

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Ship with 5-10 days
Ship with 5-10 days

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Interleukin-21(IL-21) has been shown to be produced by natural killer T (NKT) cells [1], IL-21 has been documented to regulate the differentiation and function of several CD4 T cell subsets including Th1 cells [2], Th2 cells [3], Th17 cells [4], regulatory T (Treg) cells [5], type 1 regulatory T (Tr1) cells [6], and Tfh cells [7]. Moreover, IL-21 also plays roles in the differentiation of Th9 cells and follicular regulatory T (Tfr) cells [8], as well as the production of IL-22 by CD4 T cells [9]. The functional significance of IL-21 in regulating CD8 T cell responses is highlighted by its essential role in sustaining anti-viral CD8 T cells during chronic LCMV infections [10]. Additionally, IL-21 cooperates with IL-10 to promote the maturation of memory CD8 T cells via the transcription factor STAT3 [11].

1. Coquet JM, et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 2007;178:2827–2834.
2. Wurster AL, et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med. 2002;196:969–977.
3. Pesce J, et al. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006;116:2044–2055.
4. Nurieva R, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448:480–483.
5. Attridge K, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood. 2012;119:4656–4664.
6. Spolski R, et al. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol. 2009;182:2859–2867.
7. Vogelzang A, et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity. 2008;29:127–137.
8. Ding Y, et al. Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice. Arthritis & rheumatology. 2014;66:2601–2612.
9. Basu R, et al. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. 2012;37:1061–1075.
10. Yi JS, et al. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324:1572–1576.
11. Cui W, et al. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity. 2011;35:792–805.


Synonym CVID11; IL-21; Za11
Accession # Q9HBE4-1
Molecular Characterization Gln30-Ser162
M.Wt 15.6 kDa
Source 293T cells
Bio Activity Determined by the dose-dependent stimulation of murine CTLL-2 cells:
ED50:< 0.1 ng/mL
Specific activity: > 1x107units/mg.

Quality Control

Quality Control & MSDS

View current batch:
    Purity ≥ 95%, by SDS-PAGE and HPLC.
    Endotoxin Level: < 0.1 ng/μg
  • Datasheet

Components and Storage

Formulation The protein is dissolved in PBS buffer.

This product is stable after storage at:

4°C for 1 week;

-20°C for 3 months.

Please avoid repeated freeze-thaw cycles.