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Caspase Fluorometric Substrate Set II Plus

Catalog No.
K2148
Set of 9: Caspase-1, 2, 3/7, 4, 5, 6, 8, 9 & 10 Substrates.
Grouped product items
SizePriceStock Qty
9x25 assays
$788.00
In stock

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Background

Caspases (Cysteine-dependent aspartate-directed proteases) are a family of cysteine proteases that play important roles in apoptosis, inflammation and necrosis. Sequential activation of caspases plays a critical role in cell apoptosis. Caspase-1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 are members of caspases family. Caspase-1, 4 and 5 are involved in T-cell maturation. Caspase-2, 8, 9 and 10 are initiator caspases that cleave inactive pro-forms of effector caspases into active caspases. Caspase-3, 6 and 7 are effector caspases that cleave other protein substrates within the cell to trigger the apoptotic process.

Caspase Fluorometric Substrate Set II Plus is composed of ready-to-use AFC-labeled substrates for caspase-1, 2, 3/7, 4, 5, 6, 8, 9 and 10 of caspase family proteases. The kit is used to detect activities of members of caspase family proteases. All substrates are provided in liquid form.

Features & Properties

FeaturesContains ready-to-use caspase-1/-2/-3/-4/-5/-6/-8/-9/-10 AFC-labeled substrates and all buffers for performing caspase assay.
ShippingGel pack.
Storage ConditionsStore at -20°C.

Quality Control

Quality Control & DataSheet

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Storage

Store at -20°C.

Overview

Kit componentsCaspase-1 Substrate, Ac-YVAD-AFC, Caspase-2 Substrate, Ac-VDVAD-AFC, Caspase-3/7 Substrate, Ac-DEVD-AFC, Caspase-4 Substrate, Ac-LEVD-AFC, Caspase-5 Substrate, Ac-WEHD-AFC, Caspase-6 Substrate, Ac-VEID-AFC, Caspase-8 Substrate, Ac-IETD-AFC, Caspase-9 Substrate, Ac-LEHD-AFC, Caspase-10 Substarte, Ac-AEVD-AFC , Cell Lysis Buffer, 2X Reaction Buffer, DTT (1 M)