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DUB

Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).

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  1. Cat.No. Product Name Information
  2. A8693 C527 Inhibitor of USP1/USF1 complex
  3. A8740 C598-0466 USP7 inhibitor
  4. B3515 DUBs-IN-2 deubiquitinase enzyme inhibitor
  5. B3516 DUBs-IN-3 potent deubiquitinase enzyme inhibitor
  6. B5550 HBX 41108 ubiquitin-specific protease (USP) 7 inhibitor
  7. A4002 IU1 Usp14 inhibitor
  8. A4003 LDN 57444 UCH-L1 inhibitor,reversible competitve
  9. B1317 ML-323 USP1-UAF1 inhibitor
  10. A4004 NSC 632839 hydrochloride Isopeptidases inhibitor
  11. A8198 P 22077 USP7/(DUB)USP47 inhibitor

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