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MI-773

Catalog No.
B3286
MDM2 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$240.00
Ship with 10-15 days
10mg
$398.00
Ship with 10-15 days
50mg
$1,590.00
Ship with 10-15 days
100mg
$2,625.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

MI-773 is a small molecule inhibitor of MDM2 with IC50 value of 62nM [1].

MI-773 is a small molecule MDM2 antagonist. It is a spirooxindole derivative. MI-773 shows a high MDM2 affinity with IC50 value of 62nM in the FP competitive binding experiment. In the in vitro cell-based assay, MI-773 shows a similar inhibition efficacy with its enantiomer MI-77301. The GI50 values are 58nM and 33nM for MI-773 and MI-77301, respectively. Both MI-773 and MI-77301 exert considerable activity at dose of 100 mg/kg in mouse xenograft models of osteosarcoma, prostate cancer, colorectal cancer, leukemia or melanoma. Currently, an international and multicenter phase I trial of MI-773 is underway for patients with liposarcomas and other p53-wild-type tumors [1, 2].

References:
[1] Zak K, Pecak A, Rys B, Wladyka B, Dömling A, Weber L, Holak TA, Dubin G. Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present). Expert Opin Ther Pat. 2013 Apr;23(4):425-48.
[2] Shoushtari AN, Van Tine BA, Schwartz GK. Novel treatment targets in sarcoma: more than just the GIST. Am Soc Clin Oncol Educ Book. 2014:e488-95.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt562.5
Cas No.1303607-07-9
FormulaC29H34Cl2FN3O3
SolubilitySoluble in DMSO
Chemical Name(2'R,3S,4'S,5'R,Z)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2-hydroxy-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neopentylspiro[indole-3,3'-pyrrolidine]-5'-carbimidic acid
SDFDownload SDF
Canonical SMILESCC(C)(C[[email protected]](N1)([H])[[email protected]@]([[email protected]@]([[email protected]]1([H])/C(O)=N/[[email protected]]2([H])CC[[email protected]](O)([H])CC2)([H])C3=C(F)C(Cl)=CC=C3)(C(O)=N4)C5=C4C=C(Cl)C=C5)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

MI-773

Related Biological Data

MI-773