DiscoveryProbe™ Cardiovascular-related Compounds Panel
In stock
Catalog No.
L1004
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A wide range of well-characterized bioactive molecules that covers various targets related to cardiovascular system, including angiotensin and thrombin etc. Facilitate your research towards the insights of vascular disease, stroke, wound repair and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.
Related Biological Data
Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A1009 | ANP (1-11), rat | Vasodilator | Cardiovascular | |||
| A1041 | Angiotensin (1-7) | Vasoconstriction peptide hormone | Cardiovascular | 51833-78-4 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N | |
| A1042 | Angiotensin II | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | Cardiovascular | 68521-88-0 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N.CC(=O)O | |
| A1043 | Angiotensin III (human, mouse) | Aldosterone stimulator | Cardiovascular | 13602-53-4 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N | |
| A1057 | coagulation factor II (thrombin) B chain fragment [Homo sapiens] | Trypsin-like serine protease | Cardiovascular | |||
| A1105 | BNP (1-32), human | Brain natriuretic peptide | Cardiovascular | 114471-18-0 | ||
| A1111 | Endothelin-1 (1-15), amide, human | Vasoconstrictor agent | Cardiovascular | |||
| A1143 | heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] | Thrombin inhibitor | Cardiovascular | |||
| Download the Cardiovascular-related Compounds Panel - XLSX Download the Cardiovascular-related Compounds Panel - SDF | ||||||
1. Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in
cardiovascular disease. Drug Discov Today. 2011 Jan;16(1-2):22-34. doi:
10.1016/j.drudis.2010.11.016. Epub 2010 Dec 13.
Abstract
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.
Abstract
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.
![coagulation factor II (thrombin) B chain fragment [Homo sapiens]](/pub/media/prod_images/a/1/a1057.png)
