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| DiscoveryProbe™ Cardiovascular-related Compounds Panel |
Sample solution is provided at 25 µL, 10mM.
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| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A1009 | ANP (1-11), rat | Vasodilator | Cardiovascular | |||
| A1041 | Angiotensin (1-7) | Vasoconstriction peptide hormone | Cardiovascular | 51833-78-4 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N | |
| A1042 | Angiotensin II | Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. | Cardiovascular | 68521-88-0 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N.CC(=O)O | |
| A1043 | Angiotensin III (human, mouse) | Aldosterone stimulator | Cardiovascular | 13602-53-4 | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N | |
| A1057 | coagulation factor II (thrombin) B chain fragment [Homo sapiens] | Trypsin-like serine protease | Cardiovascular | |||
| A1105 | BNP (1-32), human | Brain natriuretic peptide | Cardiovascular | 114471-18-0 | ||
| A1111 | Endothelin-1 (1-15), amide, human | Vasoconstrictor agent | Cardiovascular | |||
| A1143 | heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] | Thrombin inhibitor | Cardiovascular | |||
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Related Biological Data
- Available in stock with overnight delivery and free shipping over $500
- Cost-effective and competitive price to save your findings
- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
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| Solubility | Soluble in DMSO | Storage | Desiccate at -20°C |
| Packaging | 96 well plate | Form | Powder |
| General tips | For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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A wide range of well-characterized bioactive molecules that covers various targets related to cardiovascular system, including angiotensin and thrombin etc. Facilitate your research towards the insights of vascular disease, stroke, wound repair and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.
1. Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in
cardiovascular disease. Drug Discov Today. 2011 Jan;16(1-2):22-34. doi:
10.1016/j.drudis.2010.11.016. Epub 2010 Dec 13.
Abstract
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.
Abstract
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.