DiscoveryProbe™ Cardiovascular-related Compounds Panel

Home >> Screening Panel >> DiscoveryProbe™ Cardiovascular-related Compounds Panel

Size	Price	Stock	Qty
5mg/well	$2,780.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nature Biotechnology.
2017 Jun;35(6):569-576

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2017 May 8;31(5):635-652.e6.

Immunity.
2016 Jan 19;44(1):88-102

Nat Cell Biol.
2015 May;17(5):627-38.

Nat Immunol.
2017 Jun;18(6):654-664.

Nat Neurosci.
2015 Oct;18(10):1464-73.

Cell Res.
2016 Sep;26(9):1007-20.

Mol Cell.
2017 May 18;66(4):546-557.

Mol Cell.
2017 Jun 1;66(5):698-710.

Mol Cell.
2017 Mar 2;65(5):941-955.e8.

Nat Commun.
2016 Feb 1;7:10492.

J Cell Biol.
2016 Apr 11;213(1):109-25.

Cell Host Microbe.
2016 Jul 13;20(1):13-24.

Proc Natl Acad Sci U S A.
2016 Mar 8;113(10):2585-90.

Proc Natl Acad Sci U S A.
2015 Jun 30;112(26):E3365-73.

Proc Natl Acad Sci U S A.
2015 Jul 28;112(30):9412-7.

Autophagy.
2016 Jul 2;12(7):1129-52.

Cancer Res canres.
2946.2015.

Elife.
2016 Jan 14;5. pii: e12203.

Nucleic Acids Res.
2016 Feb 18;44(3):e2.

EMBO Rep.
2015 Sep;16(9):1114-30.

Oncogene.
2016 Mar 21.

Cell Rep.
2015 Sep 29;12(12):1986-96.

Cell Death Differ.
2016 Jun;23(6):1026-37.

Cell Death Differ.
2016 Jan;23(1):76-88.

HTS Facility Partners

Featured Products of the Panel

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A1009	ANP (1-11), rat	Vasodilator	Cardiovascular
A1041	Angiotensin (1-7)	Vasoconstriction peptide hormone	Cardiovascular	51833-78-4	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
A1042	Angiotensin II	Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex.	Cardiovascular	68521-88-0	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N.CC(=O)O
A1043	Angiotensin III (human, mouse)	Aldosterone stimulator	Cardiovascular	13602-53-4	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
A1057	coagulation factor II (thrombin) B chain fragment [Homo sapiens]	Trypsin-like serine protease	Cardiovascular
A1105	BNP (1-32), human	Brain natriuretic peptide	Cardiovascular	114471-18-0
A1111	Endothelin-1 (1-15), amide, human	Vasoconstrictor agent	Cardiovascular
A1143	heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]	Thrombin inhibitor	Cardiovascular
Download the Cardiovascular-related Compounds Panel - XLSX Download the Cardiovascular-related Compounds Panel - SDF

Quality Control

Related Biological Data

Advantages

Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility	Soluble in DMSO	Storage	Desiccate at -20°C
Packaging	96 well plate	Form	Powder
General tips	For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to cardiovascular system, including angiotensin and thrombin etc. Facilitate your research towards the insights of vascular disease, stroke, wound repair and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Dasgupta C, Zhang L. Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discov Today. 2011 Jan;16(1-2):22-34. doi: 10.1016/j.drudis.2010.11.016. Epub 2010 Dec 13.
Abstract
Angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors are expressed in most organs and tissues and are implicated in hypertension, endothelial dysfunction, and cardiovascular diseases. Certain variants of AT1R and AT2R are constitutively predisposed to higher cardiovascular risk and hypertension. In this review we focused on the structure, expression of angiotensin II receptors, their mode of action, role in cardiovascular pathobiology, and how cardiovascular diseases are programmed in utero. In addition, we described genetic variants of angiotensin receptors, and also discussed possible ways of therapeutic intervensions of Ang II stimulation.