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Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

6 Items

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  1. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.08 mg/mL
  2. GANT61
    A1615 GANT61
     1 Citation
    Target: GLI
    Summary: GLI antagonist
  3. Cyclopamine
    A8340 Cyclopamine
     1 Citation
    Target: Smoothened
    Summary: Hedgehog (Hh) signaling Inhibitor
      insoluble in EtOH; insoluble in H2O; ≥6.86 mg/mL
  4. CHIR-99021 (CT99021) HCl
    A8396 CHIR-99021 (CT99021) HCl
    Target: GSK-3
    Summary: GSK-3α/β inhibitor
      ≥25.1 mg/mL
  5. LY2940680
    A8651 LY2940680
    Target: Smoothened receptor
    Summary: Hedgehog/SMO antagonist,inhibits Hh signaling
  6. U 18666A
    B6812 U 18666A
    Summary: inhibitor of cholesterol transport and synthesis
      Soluble in H2O

6 Items

per page