HCV Protease - Selective - Animal Experiments
Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.
- A5618 Daclatasvir (BMS-790052)Target: HCV ProteasesSummary: HCV NS5A inhibitor
- A3820 Simeprevir1 CitationTarget: HCV ProteasesSummary: Inhibitor of HCV NS3/4A protease
- A3655 NesbuvirTarget: Nonstructural protein 5B (NS5B)Summary: NS5B polymerase inhibitor
- A4032 VX-222 (VCH-222, Lomibuvir)Target: HCV polymeraseSummary: NNI of HCV RNA polymerase
- A4024 Danoprevir (RG7227)Target: HCV ProteasesSummary: HCV NS3/4A protease inhibitor