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PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Items 1-10 of 15

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  1. Milrinone
    B1386 Milrinone
    Target: Phosphodiesterases (PDEs)
    Summary: PDE-3 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥8.2 mg/mL
  2. AN-2728
    A3178 AN-2728
    Summary: PDE4 inhibitor,anti-inflammatory compound
      insoluble in H2O; ≥12.55 mg/mL
  3. Sildenafil
    A3817 Sildenafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor, selective
      ≥22.65 mg/mL
  4. BRL 50481
    B6988 BRL 50481
    Target: Phosphodiesterases (PDEs)
    Summary: PDE7 inhibitor,potent and selective
      Soluble in DMSO
  5. Udenafil
    B3439 Udenafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor
      insoluble in H2O; ≥117.2 mg/mL
  6. Apremilast (CC-10004)
    A4317 Apremilast (CC-10004)
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4 inhibitor
      ≥23.05 mg/mL
  7. Sildenafil Citrate
    A4321 Sildenafil Citrate
    Target: Phosphodiesterases (PDEs)
    Summary: Treat erectile dysfunction and PAH
      ≥25.35 mg/mL
  8. Vardenafil HCl Trihydrate
    A4323 Vardenafil HCl Trihydrate
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor, potent and selective
      ≥13.3 mg/mL
  9. Rolipram
    A4328 Rolipram
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4-inhibitor and an anti-inflammatory agent
      insoluble in H2O; ≥13 mg/mL
  10. Cilomilast
    A4329 Cilomilast
    Target: Phosphodiesterases (PDEs)
    Summary: Potent PDE4 inhibitor
      insoluble in H2O; ≥12.95 mg/mL

Items 1-10 of 15

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