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MEK1/2

MEK1/2, also known as MAPKK (mitogen-activated protein kinase kinase), is a kinase enzyme which phosphorylates MAPK (mitogen-activated protein kinase).

B1267 Refametinib

Target: MEK

Summary: MEK 1/ MEK 2 inhibitor

insoluble in H2O; ≥151.8 mg/mL
B1135 GDC-0623

Target: MEK

Summary: MEK1 inhibitor, potent and ATP-uncompetitive

insoluble in H2O; ≥16.85 mg/mL
A3018 Trametinib (GSK1120212)
7 Citation

Target: MEK

Summary: MEK1 and MEK2 inhibitor, potent and selective

insoluble in H2O; insoluble in EtOH; ≥15.38 mg/mL
A3887 Trametinib DMSO solvate
1 Citation

Target: MEK

Summary: Allosteric MEK1/MEK2 kinase inhibitor

insoluble in EtOH; insoluble in H2O; ≥11.2 mg/mL