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Signaling Pathways

Signaling Pathways

A4147 LY2784544

Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3K

Summary: JAK2 inhibitor,highly potent and selective

≥23.5 mg/mL
A8303 GNF-5837

Target: Trk Receptors

Summary: Pan-Trk inhibitor

insoluble in EtOH; insoluble in H2O; ≥17 mg/mL
B5712 ANA 12
1 Citation

Target: Trk Receptors

Summary: TrkB receptor antagonist

insoluble in H2O; insoluble in EtOH; ≥10.175 mg/mL
B5832 Altiratinib
1 Citation

Target: FLT3|VEGFR|Trk Receptors|c-MET|Tie-2

Summary: c-MET/TIE-2/VEGFR inhibitor

≥21.55 mg/mL
B5859 Entrectinib

Target: Trk Receptors|ALK|ROS1

Summary: Orally active inhibitor of ALK kinase

≥28.05 mg/mL
B2297 GW441756
1 Citation

Target: Trk Receptors

Summary: TrkA inhibitor,potent and selective

insoluble in H2O; insoluble in EtOH; ≥13.75 mg/mL
B2231 Amitriptyline HCl

Target: Trk Receptors|5-HT2 Receptors|Norepinephrine transporter|5-HT Transporters

Summary: Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor

≥15.69 mg/mL