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Signaling Pathways

Signaling Pathways

A3012 Ruxolitinib (INCB018424)
4 Citation

Target: JAK

Summary: JAK inhibitor

insoluble in H2O; ≥15.32 mg/mL
A4317 Apremilast (CC-10004)

Target: Phosphodiesterases (PDEs)

Summary: PDE4 inhibitor

≥23.05 mg/mL
A4347 Methotrexate
2 Citation

Target: Folate Analogue

Summary: Folate antagonist,inhibits DFHR

≥21.55 mg/mL
A3178 AN-2728

Summary: PDE4 inhibitor,anti-inflammatory compound

insoluble in H2O; ≥12.55 mg/mL
A3284 Cathepsin S inhibitor
1 Citation

Target: Cathepsins

Summary: Blocks MHCII antigen presentation

≥24.25 mg/mL
A2415 Acitretin

Target: RARs

Summary: Metabolite of etretinate

insoluble in EtOH; insoluble in H2O; ≥16.32 mg/mL