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Signaling Pathways

Signaling Pathways

A8194 ABT-199
14 Citation

Target: Bcl-2

Summary: Bcl-2 inhibitor,potent and selective

≥43.42 mg/mL
B3553 GS-9973

Target: Syk

Summary: Syk inhibitor, orally bioavailable and selective

insoluble in EtOH; insoluble in H2O; ≥20.55 mg/mL
A8173 Romidepsin (FK228, depsipeptide)
7 Citation

Target: Histone Deacetylases (HDACs)

Summary: HDAC1/HDAC2 inhibitor, potent and selective

≥27.04 mg/mL
B3941 Talabostat mesylate
2 Citation

Target: DPP-4

Summary: orally active, specific inhibitor of DPP4

≥11.45 mg/mL
B4736 THZ1 Hydrochloride

Target: Cyclin-Dependent Kinases

Summary: CDK7 inhibitor

≥30.13 mg/mL
B6988 BRL 50481

Target: Phosphodiesterases (PDEs)

Summary: PDE7 inhibitor,potent and selective

Soluble in DMSO
B2178 BAY 80-6946 (Copanlisib)
1 Citation

Target: PI3K

Summary: PI3K inhibitor

insoluble in DMSO; insoluble in H2O; insoluble in EtOH
A1980 SNS-032 (BMS-387032)
2 Citation

Target: Cyclin-Dependent Kinases

Summary: CDK inhibitor

insoluble in H2O; ≥19.05 mg/mL