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Signaling Pathways

Signaling Pathways

A8370 Axitinib (AG 013736)
1 Citation

Target: VEGFR|PDGFR|c-Kit

Summary: VEGFR1/ c-Kit inhibitor

insoluble in H2O; ≥19.3 mg/mL
A8374 AZD8330

Target: MEK

Summary: MEK 1/2 inhibitor

≥23.05 mg/mL
B1288 Rigosertib

Target: PI3K|PLK

Summary: PI3K/PLK1 inhibitor

Soluble in DMSO
B1621 TAK-733

Target: MEK

Summary: MEK allosteric site inhibitor

≥25.2 mg/mL
B1963 Lomustine
1 Citation

Target: RNA synthesis

Summary: Antineoplastic drug

insoluble in H2O; ≥23.41 mg/mL
B6342 H-7 dihydrochloride

Target: PKC|PKG|PKA|Myosin light chain kinases (MLCKs)

Summary: protein kinase inhibitor

Soluble in DMSO
A4413 PD 150606

Target: Calpains

Summary: Non-peptide calpain inhibitor

Soluble in DMSO
A8226 TAK-632

Target: Raf

Summary: Pan-RAF inhibitor,potent and selective

≥27.75 mg/mL
A8232 Nilotinib(AMN-107)
1 Citation

Target: Bcr-Abl

Summary: Bcr-Abl kinase inhibitor,selective

≥26.5 mg/mL
A5071 GDC-0879
1 Citation

Target: Raf

Summary: B-Raf inhibitor,potent and selective

insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL