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Signaling Pathways

Items 21-30 of 624

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  1. Cucurbitacin I
    A4512 Cucurbitacin I
    Target: STAT|JAK
    Summary: STAT3/JAK2 signaling inhibitor
      ≥22.45 mg/mL
  2. Fostriecin sodium salt
    A4536 Fostriecin sodium salt
    Target: PP1|PP2A|Topoisomerases|PP4
    Summary: Antitumor antibiotic
      Soluble in H2O
  3. TC-A 2317 hydrochloride
    A4489 TC-A 2317 hydrochloride
    Target: Aurora Kinases
    Summary: Aurora kinase A inhibitor,potent and selective
      <39.29 mg/mL
  4. I-CBP 112
    A4490 I-CBP 112
    Target: CREBBP|EP300
    Summary: CBP/EP300 bromodomain inhibitor
      ≥49.6 mg/mL
  5. Mitomycin C
    A4452 Mitomycin C
     3 Citation
    Summary: Inhibits DNA synthesis,antibiotic and antitumor agent
      insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL
  6. NSC 687852 (b-AP15)
    A4453 NSC 687852 (b-AP15)
    Target: Deubiquitinating enzymes (DUBs)
    Summary: 19S regulatory particle Inhibitor
      insoluble in EtOH; insoluble in H2O; ≥20.95 mg/mL
  7. Pifithrin-μ
    A4482 Pifithrin-μ
     1 Citation
    Target: Autophagy|p53|HSP70
    Summary: Inhibitor of p53 binding and anti-apoptotic
      insoluble in H2O; ≥18.1 mg/mL
  8. BI 2536
    A3965 BI 2536
     1 Citation
    Target: PLK|Bromodomain-containing proteins(BRDs)
    Summary: Plk1 inhibitor,potent and ATP-competitive
      insoluble in H2O; ≥13.04 mg/mL
  9. Lapatinib Ditosylate
    A3967 Lapatinib Ditosylate
    Target: EGFR|ErbB-2
    Summary: EGFR/HER2 inhibitor,potent and selective
      ≥24.3 mg/mL
  10. Vatalanib
    A3969 Vatalanib
     1 Citation
    Target: VEGFR
    Summary: VEGFR-1/-2 inhibitor,cell-permeable
      ≥16.85 mg/mL

Items 21-30 of 624

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Category
  1. Proteases35item
  2. Apoptosis46item
  3. Chromatin/Epigenetics86item
  4. Metabolism37item
  5. MAPK Signaling27item
  6. Tyrosine Kinase110item
  7. DNA Damage/DNA Repair68item
  8. PI3K/Akt/mTOR Signaling51item
  9. Microbiology & Virology6item
  10. Cell Cycle/Checkpoint77item
  11. Ubiquitination/ Proteasome31item
  12. JAK/STAT Signaling35item
  13. TGF-β / Smad Signaling24item
  14. Angiogenesis6item
  15. GPCR/G protein18item
  16. Stem Cell27item
  17. Membrane Transporter/Ion Channel10item
  18. Endocrinology and Hormones14item
  19. Neuroscience10item
  20. Others40item
  21. Immunology/Inflammation7item
Specificity
  1. Selective498item
  2. Non-Selective2item
Reversibility
  1. Reversible30item
  2. Irreversible23item
Target
  1. Caspases4item
  2. Cyclin-Dependent Kinases25item
  3. Proteasome9item
  4. Cathepsins2item
  5. Histone Deacetylases (HDACs)24item
  6. Inhibitor of apoptosis proteins (IAP)2item
  7. Akt11item
  8. Bcl-28item
  9. PI3K26item
  10. CXCR4item
  11. Raf11item
  12. Aurora Kinases18item
  13. Bcl-xl2item
  14. CSF-1R4item
  15. Glycoproteins1 item
  16. p971 item
  17. MDM22item
  18. EZH25item
  19. mTOR15item
  20. Bromodomains5item
  21. AP-11 item
  22. MMP3item
  23. Thymidine Phosphorylases1 item
  24. Androgen Receptors4item
  25. DT-diaphorases1 item
  26. FLT312item
  27. GSK-35item
  28. LPA Receptors3item
  29. P-glycoprotein (P-gp)6item
  30. PLK9item
  31. Chk5item
  32. ULK11 item
  33. Eph Receptors3item
  34. VEGFR37item
  35. PDGFR21item
  36. c-Kit10item
  37. RET4item
  38. Bromodomain-containing proteins(BRDs)1 item
  39. Phosphodiesterases (PDEs)3item
  40. Mcl-15item
  41. Thymidylate Synthase3item
  42. p383item
  43. 3-phosphoglycerate dehydrogenase1 item
  44. JNK1 item
  45. SGK2item
  46. Bcr-Abl8item
  47. MEK11item
  48. PORCN1 item
  49. DOT1L3item
  50. FGFR13item
  51. Nrf21 item
  52. Insulin-like growth factor receptors(IGFRs)1 item
  53. Pim3item
  54. Liver X receptors (LXRs)1 item
  55. Sir2-like Family Deacetylases (Sirtuins)3item
  56. Deubiquitinating enzymes (DUBs)4item
  57. PP11 item
  58. PP2A1 item
  59. Smoothened5item
  60. Ribosomal s6 kinases (RSK)1 item
  61. MET7item
  62. Src9item
  63. RARs6item
  64. Trk Receptors5item
  65. Integrins1 item
  66. Aminopeptidases2item
  67. STAT6item
  68. Microtubules/Tubulins7item
  69. Estrogen and Related Receptors5item
  70. EGFR20item
  71. Hedgehog1 item
  72. ROCK1 item
  73. PAK3item
  74. Hypoxia Inducible Factors (HIFs)2item
  75. FAK6item
  76. BMP and Other Activin Receptors2item
  77. JAK12item
  78. p3001 item
  79. Stearoyl-CoA 9-desaturase (SCD-1)1 item
  80. Syk4item
  81. Progesterone Receptors2item
  82. EZH11 item
  83. DNA-PK5item
  84. HSP9012item
  85. AMPK2item
  86. Gutathione S-transferase1 item
  87. CCR1 item
  88. eIF4E/eIF3G interaction1 item
  89. Notch1 item
  90. TNKS1 item
  91. Topoisomerases10item
  92. Cytochrome P450 (CYP450)5item
  93. Ksp1 item
  94. ErbB5item
  95. Actin1 item
  96. DNA Methyltransferases3item
  97. Survivin1 item
  98. ERK4item
  99. HMG-CoA Reductases2item
  100. Vacuolar-type ATPase1 item
  101. c-MET7item
  102. BMI-11 item
  103. PKC11item
  104. Calpains2item
  105. Ubiquitin-specific proteases1 item
  106. Ca2 /calmodulin-dependent protein kinases (CaMKs)2item
  107. SMYD21 item
  108. CREBBP1 item
  109. EP3001 item
  110. Lyn1 item
  111. SGLT1 item
  112. RAD512item
  113. HER22item
  114. Pyk23item
  115. 5-HT2 Receptors2item
  116. Voltage-gated Calcium Channels (CaV)2item
  117. Calcium chelator1 item
  118. Insulin and Insulin-like Receptors2item
  119. PARP3item
  120. Pyruvate dehydrogenases (PDH)1 item
  121. ALK7item
  122. ROS12item
  123. Sphingosine kinases (SphKs)2item
  124. KRAS G12C1 item
  125. Monocarboxylate transporters (MCTs)1 item
  126. Dehydrogenase1 item
  127. PKG2item
  128. PKA5item
  129. Myosin light chain kinases (MLCKs)1 item
  130. GPR302item
  131. D1 and D5 Receptors1 item
  132. D2 Receptors2item
  133. D3 Receptors1 item
  134. Valosin-containing protein (VCP)1 item
  135. MELK1 item
  136. Insulin-like growth factors (IGFs)1 item
  137. Integrin-ligand interactions1 item
  138. CSF1R1 item
  139. Bromodomain and Extra-Terminal motif (BET)1 item
  140. MK22item
  141. 5-HT3 Receptors1 item
  142. Angiotensin-Converting Enzymes (ACEs)1 item
  143. Tie-24item
  144. RSK2item
  145. p70 S6K1 item
  146. Autophagy4item
  147. ATM/ATR6item
  148. COX4item
  149. Heparanases1 item
  150. Folate Analogue1 item
  151. YAP1 item
  152. CK11 item
  153. IDH21 item
  154. Farnesyl Diphosphate Synthases1 item
  155. CK22item
  156. HIPK21 item
  157. HIPK31 item
  158. G-quadruplexes1 item
  159. PRAK1 item
  160. MAPKAP-K21 item
  161. 20S proteasomal chymotrypsin1 item
  162. Geranylgeranyltransferase I1 item
  163. Farnesyltransferase1 item
  164. Nampt3item
  165. eIF4F1 item
  166. Cdc421 item
  167. P2X Receptors2item
  168. Glutaminases2item
  169. Carbonic Anhydrases1 item
  170. Ron1 item
  171. BLM1 item
  172. Aldehyde Dehydrogenases1 item
  173. Synthases/Synthetases3item
  174. MAGL1 item
  175. Histamine H1 Receptors1 item
  176. RAR/RXR1 item
  177. P1101 item
  178. Hck1 item
  179. Inositol-requiring enzyme 1 (IRE1)1 item
  180. iNOS1 item
  181. Histamine H2 Receptors1 item
  182. RNA Polymerases1 item
  183. Norepinephrine transporter1 item
  184. 5-HT Transporters1 item
  185. Guanylyl Cyclases1 item
  186. FoxM11 item
  187. Histone Demethylases1 item
  188. Apoptosis Inducers1 item
  189. MNK1 item
  190. Glucocorticoid Receptors1 item
  191. HIV-1 reverse transcriptase1 item
  192. Calcium-Activated Potassium (KCa) Channels1 item
  193. Insulin Receptors1 item
  194. IRG-1R1 item
  195. cAMP1 item
  196. Sulfonylurea receptors1 item
  197. eEF-21 item
  198. Cdc71 item
  199. CMV1 item
  200. ZAP-701 item
  201. Catechol O-Methyltransferase (COMT)1 item
  202. fibrinolysis1 item
  203. D4 Receptors1 item
  204. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  205. Flk-11 item
  206. Papains1 item
  207. RNA synthesis1 item
  208. Protein Arginine Methyltransferases1 item
  209. NAE2item
  210. Ubiquitin-activating Enzyme E11 item
  211. SUMOylation1 item
  212. BACE1 item
  213. Cytidine deaminases1 item
  214. angiogenesis1 item
  215. DPP-41 item
  216. PP41 item
  217. c-RET2item
  218. p70 rsk2item
  219. Microtubule/Tubulin2item
  220. VEGFR3/FLT41 item
  221. NTRK1/TRKA1 item
  222. CSF-1R/c-Fms1 item
  223. NMPRTase1 item
  224. Bfl-11 item
  225. TAM kinase1 item
  226. p53-MDM2 interaction1 item
  227. nuclear export1 item
  228. CRM11 item
  229. KDR2item
  230. AXL1 item
  231. Glyoxalase I1 item
  232. p534item
  233. HDAC1 item
  234. LOX1 item
  235. Adenylyl cyclase1 item
  236. Quinone reductase1 item
  237. human lyase1 item
  238. insulin1 item
  239. Ub-conjugating enzyme (E2) complex1 item
  240. Smoothened receptor1 item
  241. HDM2 ubiquitin ligase1 item
  242. Antibiotic1 item
  243. Hec11 item
  244. DNA Alkylating2item
  245. GLI1 item
  246. ErbB-21 item
  247. PDK-11 item
  248. Prk1 item
  249. Ribonucleotide Reductases1 item
  250. Trx1 item
  251. HSP701 item
  252. TYK21 item
  253. MUSK1 item
  254. MAP3K1 item
  255. Adenosine Deaminases1 item
  256. Flk12item
  257. DHFR1 item
  258. GARFT1 item
  259. RHA1 item
  260. MCL11 item
  261. Bcl-w1 item
  262. tropomyosin receptor kinase1 item
  263. LSD1 item
  264. DDX31 item
  265. SK1 item
  266. PPK1 item
  267. c-Syk1 item
  268. CDK1/CyclinB1 item
  269. IDO1 item
  270. PIM1 kinase1 item
  271. phospholipase A21 item
  272. Substance P/NK1 Receptor1 item
  273. Bax1 item
Reported Experiments
  1. Animal Experiments578item
  2. Cell Experiments394item