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Signaling Pathways

Signaling Pathways

B1288 Rigosertib

Target: PI3K|PLK

Summary: PI3K/PLK1 inhibitor

Soluble in DMSO
B1621 TAK-733

Target: MEK

Summary: MEK allosteric site inhibitor

≥25.2 mg/mL
B1963 Lomustine
1 Citation

Target: RNA synthesis

Summary: Antineoplastic drug

insoluble in H2O; ≥23.41 mg/mL
B4896 BMH-21

Target: RNA Polymerases

Summary: RNA polymerase I Inhibitior

insoluble in EtOH; insoluble in H2O; ≥7.4 mg/mL
B4900 Indoximod (NLG-8189)

Summary: Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor

insoluble in DMSO; insoluble in EtOH; ≥1.12 mg/mL
A8721 CBR-5884
1 Citation

Target: 3-phosphoglycerate dehydrogenase

Summary: selective inhibitor of PHGDH

insoluble in EtOH; insoluble in H2O; ≥16.8 mg/mL
B1012 MS436

Target: Bromodomains

Summary: BRD4 inhibitor

insoluble in H2O; insoluble in EtOH; ≥19.15 mg/mL
B2186 GSK2636771

Target: PI3K

Summary: PIK3 inhibitor

insoluble in H2O; insoluble in EtOH; ≥10.83 mg/mL
B1174 LGX818

Target: Raf

Summary: RAF inhibitor,potent and selective

insoluble in EtOH; insoluble in H2O; ≥13.38 mg/mL
B1135 GDC-0623

Target: MEK

Summary: MEK1 inhibitor, potent and ATP-uncompetitive

insoluble in H2O; ≥16.85 mg/mL