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Signaling Pathways

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  1. Cobicistat (GS-9350)
    A4313 Cobicistat (GS-9350)
    Target: Cytochrome P450 (CYP450)
    Summary: Selective CYP3A inhibitor
      insoluble in H2O; ≥150.9 mg/mL
  2. Clarithromycin
    A4322 Clarithromycin
    Target: Cytochrome P450 (CYP450)
    Summary: CYP3A inhibitor, potent
      ≥31.2 mg/mL
  3. Dronedarone
    A3374 Dronedarone
    Target: Cytochrome P450 (CYP450)|sodium channel|adrenergic receptor|potassium channel|calcium channel
    Summary: CYP3A4 and 2D6 inhibitor,moderate
      ≥27.84 mg/mL
  4. 7-Ethoxyresorufin
    B5963 7-Ethoxyresorufin
    Target: Cytochrome P450 (CYP450)
    Summary: Specific subtrate of CYP1A
      Soluble in DMSO

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