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Signaling Pathways

Items 21-30 of 114

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  1. Cobicistat (GS-9350)
    A4313 Cobicistat (GS-9350)
    Target: Cytochrome P450 (CYP450)
    Summary: Selective CYP3A inhibitor
      insoluble in H2O; ≥150.9 mg/mL
  2. Ketoconazole
    A4316 Ketoconazole
    Target: Cytochrome P450 (CYP450)
    Summary: Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase
      ≥23.4 mg/mL
  3. Apremilast (CC-10004)
    A4317 Apremilast (CC-10004)
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4 inhibitor
      ≥23.05 mg/mL
  4. Avasimibe
    A4318 Avasimibe
    Target: Acyl coenzyme A: cholesterol acyltransferases
    Summary: ACAT inhibitor,orally bioavailable
      ≥25.09 mg/mL
  5. Sildenafil Citrate
    A4321 Sildenafil Citrate
    Target: Phosphodiesterases (PDEs)
    Summary: Treat erectile dysfunction and PAH
      ≥25.35 mg/mL
  6. Clarithromycin
    A4322 Clarithromycin
    Target: Cytochrome P450 (CYP450)
    Summary: CYP3A inhibitor, potent
      ≥31.2 mg/mL
  7. Vardenafil HCl Trihydrate
    A4323 Vardenafil HCl Trihydrate
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor, potent and selective
      ≥13.3 mg/mL
  8. Pioglitazone HCl
    A4324 Pioglitazone HCl
    Summary: PPARγ agonist
      insoluble in H2O; ≥19.65 mg/mL
  9. PF-2545920
    A4325 PF-2545920
    Target: Phosphodiesterases (PDEs)
    Summary: PDE10A inhibitor,potent and selective
      insoluble in H2O; ≥19.35 mg/mL
  10. Tadalafil
    A4327 Tadalafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.6 mg/mL

Items 21-30 of 114

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  1. PPAR13item
  2. 5-alpha Reductase1 item
  3. 5-Lipoxygenase1 item
  4. Aminopeptidase1 item
  5. C14ɑ demethylase1 item
  6. Carbonic Anhydrase3item
  7. CETP2item
  8. Cholesterol absorption1 item
  9. CYP3A/CYP4504item
  10. Dehydrogenase6item
  11. DHFR2item
  12. DGAT1 item
  13. Dopamine β-hydroxylase4item
  14. FAAH1 item
  15. Factor Xa1 item
  16. Ferroptosis1 item
  17. Folate Analogue1 item
  18. Glucokinase1 item
  19. HMG-CoA Reductase7item
  20. HSP12item
  21. IDO4item
  22. KRAS-PDEδ1 item
  23. Lipid Metabolism2item
  24. Neuronal Metabolism1 item
  25. Oxidative Phosphorylation1 item
  26. P4503item
  27. PDE19item
  28. Phospholipase2item
  29. Saccharometabolism1 item
  30. SCD1 item
  31. SGLT1 item
  32. TPH3item
  33. Transferase8item
  34. monooxygenase1 item
  35. Hydrolase2item
Specificity
  1. Selective75item
  2. Non-Selective1 item
Reversibility
  1. Reversible1 item
  2. Irreversible5item
Target
  1. Acyl coenzyme A: cholesterol acyltransferases1 item
  2. Factor Xa1 item
  3. Phosphodiesterases (PDEs)17item
  4. Thymidylate Synthase1 item
  5. Kynurenine-3-monooxygenase1 item
  6. RARs1 item
  7. Aminopeptidases1 item
  8. Stearoyl-CoA 9-desaturase (SCD-1)2item
  9. HSP909item
  10. Cytochrome P450 (CYP450)7item
  11. HMG-CoA Reductases6item
  12. SGLT1 item
  13. DGAT2item
  14. Insulin and Insulin-like Receptors1 item
  15. Pyruvate dehydrogenases (PDH)1 item
  16. CETP2item
  17. Lactate Dehydrogenases (LDH)2item
  18. Fatty-acid-binding proteins (FABPs)1 item
  19. Folate Analogue1 item
  20. Nampt1 item
  21. Carbonic Anhydrases3item
  22. Aldehyde Dehydrogenases2item
  23. Phospholipases1 item
  24. Inward Rectifier Potassium (Kir) Channels1 item
  25. Catechol O-Methyltransferase (COMT)1 item
  26. Hydroxylases1 item
  27. FPTase1 item
  28. Tryptophan hydroxylases (TPH)2item
  29. sodium channel1 item
  30. PPAR4item
  31. Ftase1 item
  32. PC-PLC1 item
  33. GK1 item
  34. HMGCR1 item
  35. adrenergic receptor1 item
  36. sterol demethylase1 item
  37. GAPDH1 item
  38. complex I of the mitochondrial electron transport chain1 item
  39. potassium channel1 item
  40. calcium channel1 item
  41. FAAH1 item
  42. carnitine reabsorption1 item
  43. 5-alpha Reductases1 item
  44. DHFR1 item
  45. GARFT1 item
  46. glutathione peroxidase 41 item
  47. S-adenosylhomocysteine hydrolase1 item
  48. IDO1 item
  49. Tph1 item
  50. epoxide hydrolase1 item
  51. Cholesterol absorption1 item
  52. Glycogen Phosphorylases1 item
Related Disease
  1. Acne1 item
  2. Acute Kidney Injury1 item
  3. Acute Myeloid Leukemia2item
  4. Bladder Cancer1 item
  5. Bladder Carcinoma1 item
  6. Brain Injuries Studies1 item
  7. Breast Cancer9item
  8. Cancer35item
  9. Cervical Cancer1 item
  10. Chronic Lymphocytic Leukemia1 item
  11. Cocaine-Related Disorders2item
  12. Colon Cancer1 item
  13. Diabetes4item
  14. Dyslipidemia1 item
  15. Epilepsy2item
  16. Erectile Dysfunction4item
  17. Fungi1 item
  18. Glioblastoma1 item
  19. Glioma1 item
  20. Hepatic Cancer1 item
  21. HIV Infections1 item
  22. Hypercholesterolemia3item
  23. Inflammation1 item
  24. Inflammatory Diseases2item
  25. Kidney Injury Studies1 item
  26. Leukemia2item
  27. Lung Cancer5item
  28. Lymphoma3item
  29. Melanoma8item
  30. Multiple Myeloma3item
  31. Neuroblastoma3item
  32. Neurocognitive Disorders1 item
  33. Non-small Cell Lung Cancer2item
  34. Obsessive-Compulsive Disorder1 item
  35. Osteoporosis1 item
  36. Pancreatic Cancer2item
  37. Pancreatic Carcinoma1 item
  38. Prostate Cancer7item
  39. Psoriasis3item
  40. Psoriasis Vulgaris1 item
  41. Pulmonary Arterial Hypertension1 item
  42. Rheumatoid Arthritis2item
  43. Schizophrenia2item
  44. Type 2 Diabetes5item