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Signaling Pathways

Signaling Pathways

A4148 NVP-BSK805 2HCl

Target: JAK

Summary: JAK2 inhibitor

≥30.8 mg/mL
A4150 WHI-P154

Target: VEGFR|Src|EGFR|JAK

Summary: JAK3 inhibitor

insoluble in H2O; insoluble in EtOH; ≥125.6 mg/mL
A4160 A-966492

Target: PARP

Summary: PARP-1/-2 inhibitor, highly potent

≥32.4 mg/mL
A4164 AZD2461

Target: PARP

Summary: Novel PARP inhibitor

insoluble in H2O; ≥16.35 mg/mL
A4166 EPZ5676
1 Citation

Target: DOT1L

Summary: DOT1L inhibitor,potent and SAM competitive

≥28.15 mg/mL
A4171 EPZ005687
2 Citation

Target: EZH2

Summary: EZH2 inhibitor,potent and selective

insoluble in EtOH; insoluble in H2O; ≥3.86 mg/mL
A4182 Resveratrol
2 Citation

Target: Sir2-like Family Deacetylases (Sirtuins)|COX|LOX|Adenylyl cyclase|Quinone reductase

Summary: SIRT1 activator
A4184 PFI-1 (PF-6405761)
1 Citation

Target: Bromodomains

Summary: BET inhibitor

insoluble in H2O; insoluble in EtOH; ≥128.4 mg/mL
A4111 VX-680 (MK-0457,Tozasertib)

Target: Aurora Kinases

Summary: Aurora kinase inhibitor

≥23.25 mg/mL
A4112 Barasertib (AZD1152-HQPA)
3 Citation

Target: Aurora Kinases

Summary: Aurora Kinase B inhibitor, Potent and selective

≥25.4 mg/mL