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Signaling Pathways

Signaling Pathways

A8685 Wnt-C59
2 Citation

Target: PORCN

Summary: PORCN inhibitor,highly potent and selective

.95 mg/mL

insoluble in H2O; ≥18
B2307 LGK-974
1 Citation

Summary: PORCN inhibitor,potent and specific

insoluble in H2O; ≥19.8 mg/mL
B3283 PF-04449913

Target: Smoothened

Summary: Antagonist of smoothened

≥20.15 mg/mL
A8217 ICG 001
1 Citation

Summary: Wnt/β-catenin pathway inhibitor

≥27.43 mg/mL
A1877 XAV-939
1 Citation

Target: TNKS

Summary: Tankyrase 1/2 inhibitor

insoluble in H2O; insoluble in EtOH; ≥15.62 mg/mL
A1615 GANT61
1 Citation

Target: GLI

Summary: GLI antagonist
B5979 CCT251545

Summary: Orally bioavailable and potent WNT signaling inhibitor

≥42.2 mg/mL