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Signaling Pathways

Items 1-10 of 51

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  1. ABT-199
    A8194 ABT-199
     14 Citation
    Target: Bcl-2
    Summary: Bcl-2 inhibitor,potent and selective
      ≥43.42 mg/mL
  2. ABT-263 (Navitoclax)
    A3007 ABT-263 (Navitoclax)
     15 Citation
    Target: Bcl-2|Bcl-w
    Summary: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
      ≥48.73 mg/mL
  3. Celastrol
    A2604 Celastrol
    Target: Proteasome
    Summary: Antioxidant, anti-inflammatory and immunosuppressive agent
      ≥22.55 mg/mL
  4. Lenalidomide (CC-5013)
    A4211 Lenalidomide (CC-5013)
    Target: angiogenesis
    Summary: Antineoplastic agent,inhibits angiogenesis
      insoluble in EtOH; insoluble in H2O; ≥100.8 mg/mL
  5. Pomalidomide (CC-4047)
    A4212 Pomalidomide (CC-4047)
    Summary: Immunomodulator,antumor/anti-angiogenic
      insoluble in EtOH; insoluble in H2O; ≥7.5 mg/mL
  6. Necrostatin-1
    A4213 Necrostatin-1
     5 Citation
    Target: RIP kinases
    Summary: RIP1 inhibitor
      insoluble in H2O; ≥12.97 mg/mL
  7. YM155
    A4221 YM155
     2 Citation
    Target: Survivin
    Summary: Survivin suppressant,apoptosis inhibitor
      ≥22.15 mg/mL
  8. GDC-0152
    A4224 GDC-0152
     2 Citation
    Target: Inhibitor of apoptosis proteins (IAP)
    Summary: IAP antagonist,potent amd samll-molecule
      ≥24.95 mg/mL
  9. Nutlin-3
    A4228 Nutlin-3
    Target: MDM2
    Summary: MDM2 antagonist,inhibits MDM2-p53 interaction
      ≥58.2 mg/mL
  10. TW-37
    A4234 TW-37
     1 Citation
    Target: Bcl-2|Bcl-xl|Mcl-1
    Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
      insoluble in H2O; ≥19.75 mg/mL

Items 1-10 of 51

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Category
  1. Caspase11item
  2. Apoptosis Inducers8item
  3. Bcl-2 Family14item
  4. Bcl-xL4item
  5. c-RET2item
  6. IAP4item
  7. KEAP1-Nrf22item
  8. MDM21 item
  9. p533item
  10. PC-PLC1 item
  11. PKD1 item
  12. Survivin1 item
  13. Thymidylate Synthase1 item
  14. TNF-α4item
  15. Other Apoptosis1 item
Reversibility
  1. Reversible1 item
  2. Irreversible6item
Target
  1. Caspases11item
  2. Proteasome1 item
  3. Histone Deacetylases (HDACs)1 item
  4. Inhibitor of apoptosis proteins (IAP)3item
  5. Bcl-26item
  6. Raf1 item
  7. Bcl-xl3item
  8. MDM22item
  9. VEGFR2item
  10. PDGFR2item
  11. c-Kit1 item
  12. RET1 item
  13. Mcl-15item
  14. Bcr-Abl1 item
  15. Nrf21 item
  16. Deubiquitinating enzymes (DUBs)1 item
  17. RIP kinases1 item
  18. Survivin1 item
  19. Dehydrogenase1 item
  20. Mixed lineage kinase domain-like protein (MLKL)1 item
  21. COX1 item
  22. iNOS1 item
  23. TRP Channel1 item
  24. Apoptosis Inducers1 item
  25. angiogenesis1 item
  26. p53-MDM2 interaction1 item
  27. PC-PLC1 item
  28. PKD1 item
  29. MCL11 item
  30. Bcl-w1 item
Reported Experiments
  1. Animal Experiments41item
  2. Cell Experiments25item
Related Disease
  1. Acute Myeloid Leukemia1 item
  2. Adrenocortical Carcinoma1 item
  3. Autoimmune Diseases1 item
  4. Breast Cancer9item
  5. Cancer33item
  6. Chronic Lymphocytic Leukemia1 item
  7. Chronic Myeloproliferative Disorders1 item
  8. Colon Cancer4item
  9. Colorectal Cancer3item
  10. Glioblastoma4item
  11. Hepatocellular Carcinoma1 item
  12. Inflammatory Diseases1 item
  13. Lung Cancer3item
  14. Lymphoma4item
  15. Melanoma2item
  16. Multiple Myeloma2item
  17. Myelofibrosis1 item
  18. Myeloma1 item
  19. Neuroblastoma1 item
  20. Non-small Cell Lung Cancer4item
  21. Ovarian Cancer1 item
  22. Pain Relief1 item
  23. Pancreatic Cancer3item
  24. Prostate Cancer5item
  25. Pulmonary Fibrosis1 item
  26. Rheumatoid Arthritis1 item
  27. Soft Tissue Sarcoma1 item
  28. Testicular Cancer1 item