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Signaling Pathways

Signaling Pathways

A3007 ABT-263 (Navitoclax)
15 Citation

Target: Bcl-2|Bcl-w

Summary: Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w

≥48.73 mg/mL
A4116 Danusertib (PHA-739358)
2 Citation

Target: Aurora Kinases

Summary: Pan-aurora kinase inhibitor

≥23.75 mg/mL
A4208 NSC 319726

Target: p53

Summary: Reactivator of mutant p53
A4211 Lenalidomide (CC-5013)

Target: angiogenesis

Summary: Antineoplastic agent,inhibits angiogenesis

insoluble in EtOH; insoluble in H2O; ≥100.8 mg/mL
A4212 Pomalidomide (CC-4047)

Summary: Immunomodulator,antumor/anti-angiogenic

insoluble in EtOH; insoluble in H2O; ≥7.5 mg/mL
A4234 TW-37
1 Citation

Target: Bcl-2|Bcl-xl|Mcl-1

Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1

insoluble in H2O; ≥19.75 mg/mL
A4204 JNJ-26854165 (Serdemetan)
1 Citation

Target: p53|HDM2 ubiquitin ligase

Summary: P53 activator, blocking Mdm2-p53 interaction

insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL
A4194 Obatoclax mesylate (GX15-070)
1 Citation

Target: Bcl-2

Summary: Potent Bcl-2 inhibitor

insoluble in H2O; ≥20.7 mg/mL
A4200 Apogossypolone (ApoG2)
2 Citation

Target: Bcl-2|Bcl-xl|Mcl-1

Summary: Bcl-2 inhibitor,nonpeptidic small molecule

≥24.55 mg/mL
A4199 Sabutoclax
2 Citation

Target: Bcl-2|Mcl-1|Bfl-1

Summary: pan-Bcl-2 inhibitor

insoluble in H2O; ≥205.6 mg/mL