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Signaling Pathways

Signaling Pathways

A3008 Y-27632 dihydrochloride
19 Citation

Target: ROCK

Summary: ROCK1 inhibitor

≥111.2 mg/mL
A3310 chroman 1
1 Citation

Summary: ROCK II inhibitor, highly potent and selective

≥50.3 mg/mL
A3478 Hydroxyfasudil

Target: ROCK|Rho-kinase

Summary: Rho-kinase inhibitor and vasodilator

Soluble in DMSO
A3479 Hydroxyfasudil hydrochloride

Summary: Rho-kinase inhibitor and vasodilator

insoluble in EtOH; ≥7.88 mg/mL
B4909 SAR407899 hydrochloride

Summary: ATP-competitive ROCK inhibitor

Soluble in DMSO
B4910 SAR407899

Summary: ATP-competitive ROCK inhibitor

≥8.28 mg/mL
B3523 Fasudil

Target: ROCK|PKC|PKG|PKA|Myosin light chain kinases (MLCKs)

Summary: calcium antagonist

Soluble in DMSO
A3642 Narciclasine

Summary: Modulates the Rho/ROCK/LIM kinase/cofilin pathway

≥14.7 mg/mL
A3771 RKI-1447

Target: ROCK

Summary: Potent ROCK1/ROCK2 inhibitor

insoluble in H2O; ≥16.3 mg/mL
A3825 SLx-2119
1 Citation

Target: ROCK

Summary: Selective ROCK2 inhibitor

≥22.65 mg/mL