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Signaling Pathways

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  1. ENMD-2076
    A4130 ENMD-2076
    Target: Aurora Kinases|FLT3|RET|Src|VEGFR3/FLT4|NTRK1/TRKA|CSF-1R/c-Fms
    Summary: Selective Aurora A/Flt3 inhibitor
      insoluble in H2O; ≥18.75 mg/mL
  2. TAK-901
    A4124 TAK-901
    Target: Aurora Kinases|FLT3|Src|JAK|LRRK2|Hck|FGR|YES|Fyn|ARG
    Summary: Novel Aurora A/B inhibitor
      ≥25.25 mg/mL
  3. CYC116
    A4125 CYC116
    Target: Aurora Kinases|FLT3|VEGFR
    Summary: Potent Aurora A/B inhibitor
      insoluble in EtOH; insoluble in H2O; ≥18.4 mg/mL
  4. CHIR-124
    A8394 CHIR-124
    Target: FLT3|GSK-3|Chk|PDGFR
    Summary: Chk1 inhibitor,novel and potent
      insoluble in H2O; ≥10.5 mg/mL
  5. AMG 925
    B3277 AMG 925
    Target: Cyclin-Dependent Kinases|FLT3
    Summary: FLT3/CDK4 inhibitor,potent and selective
      insoluble in DMSO; insoluble in H2O; insoluble in EtOH

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