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Signaling Pathways

Signaling Pathways

A8499 PF-04691502

Target: Akt|PI3K|mTOR

Summary: PI3K/mTOR (FRAP) inhibitor

insoluble in H2O; insoluble in EtOH; ≥10.63 mg/mL
A8551 INK 128 (MLN0128)
4 Citation

Target: mTOR

Summary: MTOR(TORC-1/-2) inhibitor,potent and selective

insoluble in H2O; ≥15.45 mg/mL
A8556 GSK2126458
1 Citation

Target: PI3K|mTOR

Summary: PI3K/mTOR inhibitor

≥25.3 mg/mL
A8616 A-674563

Target: Cyclin-Dependent Kinases|Akt|GSK-3|ERK|PKC|PKA|RSK

Summary: Akt1/PKA/CDK2 inhibitor,potent and selective

insoluble in EtOH; ≥23.8 mg/mL
B1642 WYE-125132 (WYE-132)

Target: mTOR

Summary: ATP-competitive mTOR inhibitor, highly potent

insoluble in EtOH; insoluble in H2O; ≥13 mg/mL
B2172 PP121

Target: mTOR|Eph Receptors|VEGFR|PDGFR|Bcr-Abl|Src|DNA-PK|P110|Hck

Summary: Dual inhibitor of tyrosine and phosphoinositide kinases
B2176 GSK1059615

Target: PI3K|mTOR

Summary: PI3K and mTOR inhibitor,potent and reversible

insoluble in EtOH; insoluble in H2O; ≥8.33 mg/mL
A8210 GDC-0941
10 Citation

Target: PI3K

Summary: PI3K inhibitor,potent and selective

≥25.7 mg/mL
A8250 LY 294002
16 Citation

Target: PI3K

Summary: Potent PI3K inhibitor
A2846 OSU-03012 (AR-12)
1 Citation

Target: PDK-1

Summary: Potent PDK1 inhibitor

≥23 mg/mL