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Signaling Pathways

Signaling Pathways

A2949 Linifanib (ABT-869)

Target: VEGFR|PDGFR

Summary: VEGFR/PDGFR inhibitor

insoluble in H2O; insoluble in EtOH; ≥18.75 mg/mL
A5793 Quizartinib (AC220)

Target: FLT3

Summary: FLT3 inhibitor,potent and selective

≥28.03 mg/mL
A8889 G-749

Target: Aurora Kinases|FLT3|c-RET

Summary: FLT3 inhibitor

≥26.05 mg/mL
B8016 UNC2025
1 Citation

Target: MER|FLT3

Summary: orally bioavailable dual MER/FLT3 inhibitor

≥23.85 mg/mL