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Signaling Pathways

Signaling Pathways

A5467 Ponatinib (AP24534)
1 Citation

Target: VEGFR|PDGFR|Bcr-Abl|FGFR|Src

Summary: pan-BCR-ABL inhibitor,multi-kinase inhibitor

≥53.3 mg/mL
A5793 Quizartinib (AC220)

Target: FLT3

Summary: FLT3 inhibitor,potent and selective

≥28.03 mg/mL
B8016 UNC2025
1 Citation

Target: MER|FLT3

Summary: orally bioavailable dual MER/FLT3 inhibitor

≥23.85 mg/mL
A4123 KW 2449

Target: Aurora Kinases|FLT3|Bcr-Abl

Summary: Multikinase inhibitor

insoluble in EtOH; insoluble in H2O; ≥16.6 mg/mL
A3194 AST 487
1 Citation

Target: RET

Summary: RET kinase inhibitor

≥26.5 mg/mL
A3818 Silvestrol

Summary: Antineoplastic

Soluble in DMSO
A3847 SU5416

Target: VEGFR

Summary: VEGF receptor inhibitor and AHR agonist

insoluble in EtOH; insoluble in H2O; ≥11.9 mg/mL