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Signaling Pathways

Signaling Pathways

A3022 Pazopanib (GW-786034)

Target: CSF-1R|VEGFR|PDGFR|c-Kit|FGFR

Summary: VEGFR/PDGFR/FGFR inhibitor

insoluble in EtOH; insoluble in H2O; ≥10.95 mg/mL
A3750 Regorafenib hydrochloride

Target: Raf|VEGFR|PDGFR|c-Kit|c-RET

Summary: Tyrosine kinase inhibitor

≥25.95 mg/mL
A3843 SU 5402

Target: VEGFR|PDGFR|FGFR

Summary: VEGFR2/FGFR/PDGFR/EGFR inhibitor

insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL
B2171 Imatinib (STI571)

Target: PDGFR|c-Kit|Bcr-Abl

Summary: Protein-tyrosine kinase inhibitor

≥24.68 mg/mL
A8307 Crenolanib (CP-868596)
1 Citation

Target: FLT3|PDGFR

Summary: PDGFR-β inhibitor,potent and selective

≥22.2 mg/mL
A8370 Axitinib (AG 013736)
1 Citation

Target: VEGFR|PDGFR|c-Kit

Summary: VEGFR1/ c-Kit inhibitor

insoluble in H2O; ≥19.3 mg/mL
A8476 MK-2461

Target: FLT3|PDGFR|MET|Ron

Summary: C-Met (WT/mutants) inhibitor

≥24.8 mg/mL
A8550 Telatinib (BAY 57-9352)

Target: VEGFR|PDGFR|c-Kit

Summary: VEGFR-2/-3,PDGFR-β and c-Kit inhibitor

insoluble in H2O; insoluble in EtOH; ≥20.5 mg/mL
B2173 CP-673451

Target: PDGFR

Summary: PDGFRα/β inhibitor,potent and selective
A8236 Regorafenib
4 Citation

Target: Raf|VEGFR|PDGFR|c-Kit|RET

Summary: Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1

≥25.04 mg/mL