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Signaling Pathways

Signaling Pathways

A1947 MEK162 (ARRY-162, ARRY-438162)

Target: MEK

Summary: MEK1/2 inhibitor,potent and selective

insoluble in H2O; insoluble in EtOH; insoluble in DMSO
A8304 FR 180204

Target: ERK

Summary: ERK inhibitor

insoluble in H2O; ≥10.25 mg/mL
A8313 RAF265

Target: Raf|VEGFR

Summary: Multiple intracellular kinases inhibitor

≥25.9 mg/mL
A8374 AZD8330

Target: MEK

Summary: MEK 1/2 inhibitor

≥23.05 mg/mL
B1621 TAK-733

Target: MEK

Summary: MEK allosteric site inhibitor

≥25.2 mg/mL
A8716 LY3009120

Target: Raf

Summary: pan-RAF and RAF dimer inhibitor

insoluble in H2O; insoluble in EtOH; ≥4.25 mg/mL
B6012 Pexmetinib (ARRY-614)

Target: p38|Tie-2

Summary: dual inhibitor of p38 MAPK and Tie2/Tek receptor tyrosine kinase

insoluble in H2O; ≥107.6 mg/mL
B1267 Refametinib

Target: MEK

Summary: MEK 1/ MEK 2 inhibitor

insoluble in H2O; ≥151.8 mg/mL
B1135 GDC-0623

Target: MEK

Summary: MEK1 inhibitor, potent and ATP-uncompetitive

insoluble in H2O; ≥16.85 mg/mL
B6962 CMPD-1

Target: Microtubules/Tubulins|MK2

Summary: inhibitor of p38α-mediated MK2a phosphorylation

<34.94 mg/mL