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DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel

DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel

Catalog No. L1007
Size Price Stock Qty
5mg/well $5,110.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A4605 KU 55933 ATM inhibitor,potent and selective DNA Damage/DNA Repair|ATM/ATR 587871-26-9 C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
B1383 VE-822 ATR inhibitor DNA Damage/DNA Repair|ATM/ATR 1232416-25-9 CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N
A8705 SCR7 DNA ligase IV inhibitor DNA Damage/DNA Repair|DNA Ligases 1533426-72-0 S=C(NC(/N=C/C1=CC=CC=C1)=C2/N=C/C3=CC=CC=C3)NC2=O
A4083 Rocilinostat (ACY-1215) Selective HDAC6 inhibitor DNA Damage/DNA Repair|HDAC 1316214-52-4 C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
A4090 JNJ-26481585 Potent HDAC inhibitor DNA Damage/DNA Repair|HDAC 875320-29-9 CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO
A8802 (S)-Crizotinib Potent MTH1 inhibitor DNA Damage/DNA Repair|MTH1 CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
A1945 BIBR 1532 Telomerase inhibitor,novel and selective DNA Damage/DNA Repair|Telomerase 321674-73-1 CC(=CC(=O)NC1=CC=CC=C1C(=O)O)C2=CC3=CC=CC=C3C=C2
A3966 Doxorubicin Topo II inhibitor,immunosuppresive antineoplastic antibiotic DNA Damage/DNA Repair|Topoisomerase 23214-92-8 CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Download the DNA Damage/DNA Repair-related Compounds Panel - XLSX       Download the DNA Damage/DNA Repair-related Compounds Panel - SDF

Quality Control

Related Biological Data

Trichostatin A
RPE cells were treated with TSA at various concentrations (0.2, 0.4, 0.8 and 1.0 μM). The protein expression levels of cyclinD1, CDK4 and CDK6, p-Rb, P21 and P27 were detected by western blot.

Related Biological Data

Trichostatin A
TSA replaces FGF-2 in the reprogramming process

Related Biological Data

Trichostatin A

Related Biological Data

KU 55933

Related Biological Data

KU 55933

Related Biological Data

KU 55933

Signaling Pathway

PARP Research Area
PARP Compare Products
HDAC Compare Products
Topoisomerase Compare Products


  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility Soluble in DMSO Storage Desiccate at -20°C
Packaging 96 well plate Form Powder
General tips For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc. Applicable in cellular assays, animal models and drug screenings etc.


1. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature. 2012 Jan 18;481(7381):287-94.
Genomic instability is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.
2. Park J, Thomas S, Munster PN. Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy. Epigenomics. 2015;7(4):641-52.
HDAC inhibitors have been approved as single agents for cutaneous and peripheral T-cell lymphoma and have shown promising activity in reversing therapy resistance in other tumor types. This review describes the current understanding on integrating HDAC inhibitors into various immunotherapeutic approaches, such as cancer vaccines, adoptive T-cell transfer and immune checkpoint inhibitors. Furthermore, it summarizes promising treatment strategies in epigenetic immune priming from clinical trials that are currently underway.