3-Oxodeoxycholic acid
3-oxo Deoxycholic Acid is a secondary bile acid, which is metabolized by intestinal microorganisms from primary bile acids. It is also a metabolic product of Deoxycholic acid under the action of intestinal bacteria such as Clostridium perfringens. As a secondary bile Acid, the production of 3-oxo Deoxycholic Acid depends on the enzymatic catalysis of the intestinal microbiota (such as the reverse oxidation of 3α -hydroxysteroid dehydrogenase). The polarity of 3-oxo Deoxycholic Acid is lower than that of deoxycholic acid, but its biological activity has not been fully clarified. It may be involved in lipid metabolism regulation by regulating nuclear receptors (such as FXR, PXR) or affecting cell membrane fluidity. Under pathological conditions, the changes in its level may be related to the disorder of the intestinal flora (such as during antibiotic intervention or inflammatory bowel disease), while the metabolic transformation of deoxycholic acid by pathogenic bacteria such as Clostridium perfringens may be related to their colonization ability and virulence regulation.
| Physical Appearance | A solid |
| Storage | Store at -20°C for 3 years. |
| M.Wt | 390.56 |
| Cas No. | 4185-01-7 |
| Formula | C24H38O4 |
| Solubility | ≥51.4 mg/mL in DMSO; ≥25.15 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (R)-4-((5R,8R,9S,10S,12S,13R,14S,17R)-12-hydroxy-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
