Isolithocholic acid
Isolithocholic acid is an isomer of Lithocholic acid and belongs to secondary bile acids. As a member of the cholic acid family, Isolithocholic acid is mainly produced by intestinal microorganisms through hydroxyl episomerization and can be catalyzed by microbial enzymes (such as hydroxysteroid dehydrogenase) from cholic acid or its metabolite, cholic acid 3α -sulfate. The production of isocholic acid is closely related to the diversity of the intestinal flora, and changes in its level can reflect the imbalance of the intestinal microecology (such as during the use of antibiotics or inflammatory bowel disease). Although its biological functions have not been fully elucidated, as an active isomer of choline, it may be involved in regulating the signal transduction of bile acid receptors (such as FXR and TGR5), and affect lipid metabolism and intestinal immunity.
| Physical Appearance | A solid |
| Storage | Store at -20°C for 3 years. |
| M.Wt | 376.57 |
| Cas No. | 1534-35-6 |
| Formula | C24H40O3 |
| Solubility | ≥3.15 mg/mL in DMSO with ultrasonic; ≥3.27 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (R)-4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
