12-Ketolithocholic acid
12-Ketodeoxycholic acid is a secondary bile acid modified with a ketone group. As a special metabolite of bile acids, 12-Ketodeoxycholic acid is produced in the kidneys and is derived from the conversion of deoxycholic acids catalyzed by oxidase within the kidneys (such as hydroxysteroid dehydrogenase). It is a specific metabolite of the kidneys. Studies have shown that 12-Ketodeoxycholic acid can serve as a potential biomarker for kidney injury: in models of acute kidney injury (AKI) or chronic kidney disease (CKD), its urine or plasma levels are significantly elevated, which may be related to the activation of metabolic pathways after kidney cell injury. The abnormal accumulation of this compound may reflect a decline in the kidneys' metabolic clearance ability of bile acids, or an increase in ketoylation modification caused by oxidative stress. Although its specific biological functions have not been fully elucidated, as a metabolite of renal bile acids, its level changes provide new molecular indicators for monitoring renal function impairment and exploring the pathological mechanism of the disease, and also offer a research direction for the development of non-invasive markers of renal injury.
| Physical Appearance | A solid |
| Storage | Store at -20°C for 3 years. |
| M.Wt | 390.56 |
| Cas No. | 5130-29-0 |
| Formula | C24H38O4 |
| Synonyms | 12-Ketolithocholic acid |
| Solubility | ≥53.2 mg/mL in DMSO; ≥53.1 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | C[C@H](CCC(O)=O)[C@H]1CC[C@@]([C@]21C)([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
